Rabbit PRA1 Polyclonal Antibody | anti-PRA1 antibody

PRA1 Antibody

Cat. Num. AAA7113698

• Reactivity: Candida Albicans
• Applications: ELISA, Western Blot
• Purity: >95%; Protein G Purified
• Synonyms: PRA1; Polyclonal Antibody; PRA1 Antibody; pH-regulated antigen PRA1; 58 kDa fibrinogen-binding mannoprotein; FBP1; anti-PRA1 antibody

• Host: Rabbit
• Reactivity: Candida Albicans
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%; Protein G Purified
• Form/Format: Liquid
• Sequence Length: 299

• Applicable Applications for anti-PRA1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:5000
• Immunogen Species: Candida Albicans
• Immunogen: Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)
• Conjugate: Non-Conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in Recombinant proteinAll lanes: PRA1 antibody at 4.7ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 55 kDaObserved band size: 55 kDa)

NCBI and Uniprot Product Information

• NCBI GI #: 1111956962
• NCBI GeneID: 3642969
• NCBI Accession #: XP_715420.2
• NCBI GenBank Nucleotide #: XM_710327.2
• UniProt Accession #: P87020; P78598; Q5A0Y5; Q5A156; A0A1D8PMQ8
• Molecular Weight: 33,159 Da
• NCBI Official Full Name: Pra1p
• NCBI Official Symbol: PRA1
• NCBI Protein Information: Pra1p
• UniProt Protein Name: pH-regulated antigen PRA1
• Protein Family: PRA1-like protein
• UniProt Gene Name: PRA1
• UniProt Synonym Gene Names: FBP1

Uniprot Description

Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.