Rabbit PPP6C / PP6 Polyclonal Antibody | anti-PPP6C antibody

Rabbit Polyclonal

Cat. Num. AAA240290

• Gene Names: PPP6C; PP6; PP6C
• Reactivity: Bovine, Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, Immunoprecipitation
• Purity: Purified
• Synonyms: PPP6C / PP6; Polyclonal Antibody; Rabbit Polyclonal; Anti-PPP6C / PP6 Antibody IHC-plus; PPP6C; PP6; PP6C; PPP6; Protein phosphatase 6; anti-PPP6C antibody

• Host: Rabbit
• Reactivity: Bovine, Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Purified
• Form/Format: PBS, 0.08% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 305

• Applicable Applications for anti-PPP6C antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: IHC-P (20 ug/ml), IP, WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Immunogen Description: Synthetic peptide conjugated to KLH corresponding to the sequence NH2-Cys-Ala-Val-Pro-Asp-Ser-Glu-Arg-Val-Ile-Pro-Pro-Arg-Thr-Thr-Thr-Pro-Tyr-COOH.
• Immunogen Type: Synthetic peptide - KLH conjugated
• Immunogen: PPP6C / PP6 antibody was raised against synthetic peptide conjugated to KLH corresponding to the sequence NH2-Cys-Ala-Val-Pro-Asp-Ser-Glu-Arg-Val-Ile-Pro-Pro-Arg-Thr-Thr-Thr-Pro-Tyr-COOH.
• Preparation and Storage: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-PPP6C antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)

Related Product Information for anti-PPP6C antibody

Protein phosphatase 6 (PPP6C) is a serine/threonine phosphatase that may function in cell cycle regulation based on its functional homology with budding yeast Sit4p and fission yeast ppe1. The phosphoprotein alpha4 has been identified as a potential regulatory subunit. At least three alternative transcripts have been reported.

Product Categories/Family for anti-PPP6C antibody

Family: Protein Phosphatase; Subfamily: Protein Phosphatase - Serine/Threonine other

NCBI and Uniprot Product Information

• NCBI GI #: 4506029
• NCBI GeneID: 5537
• NCBI Accession #: NP_002712.1
• NCBI GenBank Nucleotide #: NM_002721.4
• UniProt Accession #: O00743; Q5U0A2; Q9UIC9; B2R5V6; B7Z2W9; B7Z5K9
• Molecular Weight: 38,947 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase 6 catalytic subunit isoform b
• NCBI Official Synonym Full Names: protein phosphatase 6, catalytic subunit
• NCBI Official Symbol: PPP6C
• NCBI Official Synonym Symbols: PP6; PP6C
• NCBI Protein Information: serine/threonine-protein phosphatase 6 catalytic subunit; serine/threonine protein phosphatase catalytic subunit
• UniProt Protein Name: Serine/threonine-protein phosphatase 6 catalytic subunit
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP6C
• UniProt Synonym Gene Names: PPP6; PP6C
• UniProt Entry Name: PPP6_HUMAN

NCBI Description

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

Uniprot Description

PPP6C: a Ser/Thr phosphatase. A functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.

Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: cytosol

Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation; G1/S transition of mitotic cell cycle