Rabbit anti-Human PPP6C Polyclonal Antibody | anti-PPP6C antibody

PPP6C Antibody

Cat. Num. AAA7052293

• Gene Names: PPP6C; PP6; PP6C
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: PPP6C; Polyclonal Antibody; PPP6C Antibody; Serine/threonine-protein phosphatase 6 catalytic subunit; PP6C; N-terminally processed; PPP6; anti-PPP6C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 342

• Applicable Applications for anti-PPP6C antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:20-1:200; IF: 1:50-1:200
• Immunogen: Recombinant Human Serine/threonine-protein phosphatase 6 catalytic subunit protein (40-211AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human spleen tissue using MBS7052293 at dilution of 1:100)

Immunofluorescence (IF)

(Immunofluorescent analysis of HepG2 cells using MBS7052293 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-PPP6C antibody

Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.

NCBI and Uniprot Product Information

• NCBI GI #: 183603929
• NCBI GeneID: 5537
• NCBI Accession #: NP_001116827.1
• NCBI GenBank Nucleotide #: NM_001123355.1
• UniProt Accession #: O00743; Q5U0A2; Q9UIC9; B2R5V6; B7Z2W9; B7Z5K9
• Molecular Weight: 38,947 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase 6 catalytic subunit isoform a
• NCBI Official Synonym Full Names: protein phosphatase 6 catalytic subunit
• NCBI Official Symbol: PPP6C
• NCBI Official Synonym Symbols: PP6; PP6C
• NCBI Protein Information: serine/threonine-protein phosphatase 6 catalytic subunit
• UniProt Protein Name: Serine/threonine-protein phosphatase 6 catalytic subunit
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP6C
• UniProt Synonym Gene Names: PPP6; PP6C

NCBI Description

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

Uniprot Description

PPP6C: a Ser/Thr phosphatase. A functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.

Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: cytosol

Molecular Function: protein binding; protein serine/threonine phosphatase activity

Biological Process: COPII coating of Golgi vesicle; G1/S transition of mitotic cell cycle; protein amino acid dephosphorylation