Goat PPP2R3A / PR130 Polyclonal Antibody | anti-PPP2R3A antibody

Goat Polyclonal to Human PPP2R3A / PR130

Cat. Num. AAA242122

• Gene Names: PPP2R3A; PR72; PR130; PPP2R3
• Reactivity: Gibbon, Gorilla, Horse, Human, Monkey, Mouse, Pig, Rabbit; Predicted Reactivity: Rat, Bat, Bovine, Hamster, Chicken (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: PPP2R3A / PR130; Polyclonal Antibody; Goat Polyclonal to Human PPP2R3A / PR130; Anti-PPP2R3A / PR130 Antibody (Internal) IHC-plus; PPP2R3A; PR130; PR72; PPP2R3; PP2A; subunit B; R3 isoform; Human PPP2R3A; anti-PPP2R3A antibody

• Host: Goat
• Reactivity: Gibbon, Gorilla, Horse, Human, Monkey, Mouse, Pig, Rabbit; Predicted Reactivity: Rat, Bat, Bovine, Hamster, Chicken (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PPP2R3A. This antibody is expected to recognise both reported isoforms (NP_002709.2; NP_871626.1).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 1150

• Applicable Applications for anti-PPP2R3A antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:16000), IHC-P (5 ug/ml), WB (1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-QKDVENDGPEPSD from an internal region of human PPP2R3A (NP_002709.2; NP_871626.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Elephant, Horse, Rabbit, Pig, Lizard (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: PPP2R3A / PR130 antibody was raised against synthetic peptide C-QKDVENDGPEPSD from an internal region of human PPP2R3A (NP_002709.2; NP_871626.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Elephant, Horse, Rabbit, Pig, Lizard (100%); Rat, Hamster, Bat, Bovine, Opossum, Turkey, Chicken (92%); Dog (85%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-PPP2R3A antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 19923229
• NCBI GeneID: 5523
• NCBI Accession #: NP_002709.2
• NCBI GenBank Nucleotide #: NM_002718.4
• UniProt Accession #: Q06190; Q06189; Q9NPQ5; A8KAE7; B4DNU1; B7ZAE3
• Molecular Weight: 48,178 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1
• NCBI Official Synonym Full Names: protein phosphatase 2, regulatory subunit B'', alpha
• NCBI Official Symbol: PPP2R3A
• NCBI Official Synonym Symbols: PR72; PR130; PPP2R3
• NCBI Protein Information: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha; PP2A, subunit B, R3 isoform; PP2A subunit B isoforms B72/B130; serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B; protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform
• UniProt Protein Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP2R3A
• UniProt Synonym Gene Names: PPP2R3
• UniProt Entry Name: P2R3A_HUMAN

NCBI Description

This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

Uniprot Description

PPP2R3A: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: protein phosphatase type 2A complex

Molecular Function: protein binding; protein phosphatase type 2A regulator activity; calcium ion binding

Biological Process: regulation of catalytic activity; positive regulation of protein catabolic process; eye photoreceptor cell differentiation; protein amino acid dephosphorylation; somatic muscle development