Western Blot (WB)
(PPIL5 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PPIL5 antibody detected the PPIL5 protein (arrow).)
Rabbit anti-Human PPIL5 Polyclonal Antibody | anti-LRR1 antibody
PPIL5 Antibody (Center)
Western Blot (WB)
(PPIL5 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PPIL5 antibody detected the PPIL5 protein (arrow).)
Western Blot (WB)
(PPIL5 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PPIL5 antibody detected the PPIL5 protein (arrow).)
repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a
member of the tumor necrosis factor receptor (TNFR) superfamily.
Overexpression of this gene suppresses the activation of NF-kappa B
induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2),
which suggests that this protein is a negative regulator of
TNFRSF9-mediated signaling cascades. At least three alternatively
spliced transcript variants encoding distinct isoforms have been
observed.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Uniprot Description
PPIL5: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q21.3
Biological Process: protein ubiquitination
Research Articles on LRR1
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Product Notes
The LRR1 lrr1 (Catalog #AAA9213477) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 127-153. The PPIL5 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PPIL5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the LRR1 lrr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPIL5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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