Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse colon using PPARA Polyclonal Antibody at dilution of 1:300.)
Rabbit anti-Mouse, Rat PPARA Polyclonal Antibody | anti-PPARA antibody
PPARA Polyclonal Antibody
Gene Names
Ppara; Ppar; Nr1c1; AW742785; PPARalpha; PPAR-alpha; 4933429D07Rik
Reactivity
Mouse, Rat
Applications
Immunohistochemistry
Purity
Affinity Purification
Synonyms
PPARA; Polyclonal Antibody; PPARA Polyclonal Antibody; hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferative activated receptor alpha; Peroxisome proliferator activated receptor alpha; Peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha; ppara; PPARalpha; anti-PPARA antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
Concentration
0.6 mg/mL (varies by lot)
Sequence Length
468
Applicable Applications for anti-PPARA antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:200-1:500
Immunogen
KLH conjugated synthetic peptide corresponding to Mouse PPARalpha
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse colon using PPARA Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse colon using PPARA Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse kidney using PPARA Polyclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse kidney using PPARA Polyclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded rat liver using PPARA Polyclonal Antibody at dilution of 1:300.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded rat liver using PPARA Polyclonal Antibody at dilution of 1:300.)
Related Product Information for anti-PPARA antibody
Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid beta-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-kappaB, causing inhibition of its signaling pathway or reducing the activated levels of NF-kappaB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.
Product Categories/Family for anti-PPARA antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52,347 Da
NCBI Official Full Name
peroxisome proliferator-activated receptor alpha
NCBI Official Synonym Full Names
peroxisome proliferator activated receptor alpha
NCBI Official Symbol
Ppara
NCBI Official Synonym Symbols
Ppar; Nr1c1; AW742785; PPARalpha; PPAR-alpha; 4933429D07Rik
NCBI Protein Information
peroxisome proliferator-activated receptor alpha
UniProt Protein Name
Peroxisome proliferator-activated receptor alpha
Protein Family
UniProt Gene Name
Ppara
UniProt Synonym Gene Names
Nr1c1; Ppar; PPAR-alpha
Uniprot Description
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Research Articles on PPARA
Similar Products
Product Notes
The PPARA ppara (Catalog #AAA2556271) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PPARA Polyclonal Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PPARA can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:200-1:500. Researchers should empirically determine the suitability of the PPARA ppara for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPARA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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