Rabbit COX7B Polyclonal Antibody | anti-COX7B antibody

COX7B Polyclonal Antibody

Cat. Num. AAA3006809

• Gene Names: COX7B; APLCC; LSDMCA2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: COX7B; Polyclonal Antibody; COX7B Polyclonal Antibody; Cytochrome c oxidase subunit 7B; mitochondrial; Cytochrome c oxidase polypeptide VIIb; anti-COX7B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: COX7B polyclonal antibody detects endogenous levels of COX7B protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 80

• Applicable Applications for anti-COX7B antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in HumanCOX7B.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of COX7B polyclonal antibody at 1:500 dilution Lane1:RAW264. 7 whole cell lysate Lane2:H9C2 whole cell lysate Lane3:HELA whole cell lysate)

Related Product Information for anti-COX7B antibody

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water and ATP. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. COX7b (cytochrome c oxidase subunit VIIb polypeptide) and COX7b2 (cytochrome c oxidase subunit VIIb polypeptide 2) are 80 and 81 amino acid proteins, respectively, which exist as components of the COX complex, therefore playing an important role in electron transport. A rare polymorphism in the COX7b2 gene at codon 26 may be linked to nasopharyngeal carcinoma (NPC), the most common head and neck cancer in southern China.

NCBI and Uniprot Product Information

• NCBI GI #: 30151
• NCBI GeneID: 1349
• UniProt Accession #: P24311
• Molecular Weight: ~ 9kDa
• NCBI Official Full Name: cytochrome c oxidase subunit VIIb
• NCBI Official Synonym Full Names: cytochrome c oxidase subunit 7B
• NCBI Official Symbol: COX7B
• NCBI Official Synonym Symbols: APLCC; LSDMCA2
• NCBI Protein Information: cytochrome c oxidase subunit 7B, mitochondrial
• UniProt Protein Name: Cytochrome c oxidase subunit 7B, mitochondrial
• Protein Family: Cytochrome c oxidase
• UniProt Gene Name: COX7B
• UniProt Entry Name: COX7B_HUMAN

NCBI Description

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]

Uniprot Description

COX7B: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIb family.

Protein type: Membrane protein, integral; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: mitochondrial inner membrane; integral to membrane; mitochondrial respiratory chain

Molecular Function: cytochrome-c oxidase activity

Biological Process: cellular metabolic process; central nervous system development; transmembrane transport

Disease: Aplasia Cutis Congenita, Reticulolinear, With Microcephaly, Facial Dysmorphism, And Other Congenital Anomalies