Rabbit anti-Human PP1C gamma Polyclonal Antibody | anti-Ppp1r15a antibody

PP1C gamma, CT (Serine/Threonine Protein Phosphatase PP1-gamma Catalytic Subunit, PP-1G, Protein Phosphatase 1C Catalytic Subunit, PPP1CC)

Cat. Num. AAA628520

• Gene Names: Ppp1r15a; Gadd34; Myd116; 9630030H21
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: PP1C gamma; Polyclonal Antibody; CT (Serine/Threonine Protein Phosphatase PP1-gamma Catalytic Subunit; PP-1G; Protein Phosphatase 1C Catalytic Subunit; PPP1CC); Anti -PP1C gamma; anti-Ppp1r15a antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PPP1CC.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-Ppp1r15a antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1,000; Western Blot: 1:100-1:500
• Immunogen: Synthetic peptide selected from the C-terminal region of human PPP1CC (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of hPPP1CC-A306 in Hela, T47D cell line lysates (35ug/lane).PPP1CC (arrow) was detected using the purified Pab.)

Related Product Information for anti-Ppp1r15a antibody

Protein phosphatase-1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases involved in the dephosphorylation of a variety of proteins. These enzymes work in opposition to the protein kinases to control the level of phosphorylation. Protein phosphatase (PP1) is essential for cell division, and it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis, as well as in regulation of ionic conductances and long-term synaptic plasticity. PP1 has 3 catalytic subunits, designated alpha (PPP1CA), beta (PPP1CB), and gamma (PPP1CC).

Product Categories/Family for anti-Ppp1r15a antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 6678978
• NCBI GeneID: 17872
• NCBI Accession #: NP_032680.1
• NCBI GenBank Nucleotide #: NM_008654.2
• UniProt Accession #: P17564; Q3TJS6; Q3U3L5; Q8C579
• Molecular Weight: 71,840 Da
• NCBI Official Full Name: protein phosphatase 1 regulatory subunit 15A
• NCBI Official Synonym Full Names: protein phosphatase 1, regulatory (inhibitor) subunit 15A
• NCBI Official Symbol: Ppp1r15a
• NCBI Official Synonym Symbols: Gadd34; Myd116; 9630030H21
• NCBI Protein Information: protein phosphatase 1 regulatory subunit 15A; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; growth arrest and DNA damage-inducible protein GADD34; myeloid differentiation primary response protein MyD116
• UniProt Protein Name: Protein phosphatase 1 regulatory subunit 15A
• Protein Family: Protein phosphatase 1 regulatory
• UniProt Gene Name: Ppp1r15a
• UniProt Synonym Gene Names: Gadd34; Myd116
• UniProt Entry Name: PR15A_MOUSE

Uniprot Description

GADD34: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Belongs to the PPP1R15 family.

Protein type: Cell cycle regulation; Apoptosis; DNA repair, damage; Translation initiation

Cellular Component: Golgi apparatus; mitochondrial outer membrane; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; protein phosphatase type 1 complex

Molecular Function: protein phosphatase regulator activity; protein phosphatase binding; protein phosphatase 1 binding; protein kinase binding

Biological Process: regulation of translation; positive regulation of phosphoprotein phosphatase activity; negative regulation of protein amino acid dephosphorylation; apoptosis; unfolded protein response; negative regulation of phosphoprotein phosphatase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase I promoter