Rabbit anti-Human, Mouse PDE6D Polyclonal Antibody | anti-PDE6D antibody

PDE6D Polyclonal Antibody

Cat. Num. AAA2562948

• Gene Names: PDE6D; PDED; JBTS22
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: PDE6D; Polyclonal Antibody; PDE6D Polyclonal Antibody; 5''-cyclic phosphodiesterase subunit delta; GMP PDE delta; GMP-PDE delta; P17 protein; PDE 6; PDE 6D; PDE D; PDE6; PDED; Phosphodiesterase 6D cGMP specific; Phosphodiesterase 6D cGMP specific rod delta; Protein p17; Retinal rod photoreceptor cGMP phosphodiesterase delta; Retinal rod rhodopsin sensitive cGMP 3' 5' cyclic phosphodiesterase subunit delta; Retinal rod rhodopsin-sensitive cGMP 3''; anti-PDE6D antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.08mg/mL (varies by lot)
• Sequence Length: 93

• Applicable Applications for anti-PDE6D antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:200; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human PDE6D
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using PDE6D Polyclonal Antibody at dilution of 1:60(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PDE6D Polyclonal Antibody at dilution of 1:60(×200))

Related Product Information for anti-PDE6D antibody

This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants.

Product Categories/Family for anti-PDE6D antibody

Cancer; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 597518021
• NCBI GeneID: 5147
• NCBI Accession #: NP_001277947.1; BC007831
• NCBI GenBank Nucleotide #: NP_001277947.1
• UniProt Accession #: O43924
• NCBI Official Full Name: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 2
• NCBI Official Synonym Full Names: phosphodiesterase 6D
• NCBI Official Symbol: PDE6D
• NCBI Official Synonym Symbols: PDED; JBTS22
• NCBI Protein Information: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
• UniProt Protein Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
• Protein Family: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6D
• UniProt Synonym Gene Names: PDED; GMP-PDE delta
• UniProt Entry Name: PDE6D_HUMAN

NCBI Description

This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]

Uniprot Description

PDE6D: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Belongs to the PDE6D/unc-119 family.

Chromosomal Location of Human Ortholog: 2q35-q36

Cellular Component: cytoskeleton; cytoplasmic vesicle membrane; cytoplasmic vesicle; cytosol

Molecular Function: protein binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; Rab GTPase binding; GTPase inhibitor activity

Biological Process: visual perception; metabolic process; organelle organization and biogenesis; negative regulation of catalytic activity; response to stimulus

Disease: Joubert Syndrome 22