Rabbit Postsynaptic Density Protein 95 CT Polyclonal Antibody | anti-Lin7c antibody

Postsynaptic Density Protein 95 CT (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Human Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90)

Cat. Num. AAA621930

• Gene Names: Lin7c; Veli3; LIN-7C; MALS-3; LIN-7-C; AI303698; AU019331; AW125731; D2Ertd520e; 9130007B12Rik
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation, Immunofluorescence
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Postsynaptic Density Protein 95 CT; Polyclonal Antibody; Postsynaptic Density Protein 95 CT (PSD-95; PSD95; Discs Large Homolog 4; DLG4; Human Post-synaptic Density Protein 95; Synapse-associated Protein 90; SAP90; SAP-90); Anti -Postsynaptic Density Protein 95 CT (PSD-95; anti-Lin7c antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PSD-95 at ~95kD. Crossreactivity with an unknown protein at ~50kD with rat brain homogenates but not with mouse brain homogenates. Reactivity confirmed with rat brain homogenates and lysates of PSD-95 transfected HEK293 cells. Species Crossreactivity: rat and mouse
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

• Applicable Applications for anti-Lin7c antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunoprecipitation.; Dilution: Immunofluorescence: 0.5-1.0ug/ml; ELISA: 0.1-1.0ug/ml; Western Blot: 1ug/ml; Immunoprecipitation (Rat): 5ug/IP reaction
• Immunogen: Synthetic peptide corresponding to the C-terminal region of human PSD-95, conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Lin7c antibody

PSD-95 belongs to a class of proteins referred to as MAGUKs (membrane associated guanylate kinases). Cannonical MAGUK proteins contain one or three PDZ (PSD-95/discs large/zona occludens-1) domains, an SH3 domain, and a guanylate kinase homology domain. PSD-95 and several other MAGUK and PDZ containing proteins (eg. PSD-93, SAP-97, SAP-102, MALS/Veli proteins(2)) are enriched in the post synaptic density.(3) These proteins appear to regulate synaptic function by acting as molecular scaffolds to organize and cluster signaling machinery at synapses, in part by interaction of their PDZ domains with carboxy-terminal T/SXV motifs present on synaptic proteins including NMDA receptors and Shaker type K+ channels. PSD-95 has also been shown to link NMDA receptors to the downstream signal transduction protein neuronal nitric oxide synthetase (nNOS) via a novel PDZ:PDZ interaction with nNOS.

Product Categories/Family for anti-Lin7c antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 6755973
• NCBI GeneID: 22343
• NCBI Accession #: NP_035829.1
• NCBI GenBank Nucleotide #: NM_011699.3
• UniProt Accession #: O88952
• Molecular Weight: 21,834 Da
• NCBI Official Full Name: protein lin-7 homolog C
• NCBI Official Synonym Full Names: lin-7 homolog C (C. elegans)
• NCBI Official Symbol: Lin7c
• NCBI Official Synonym Symbols: Veli3; LIN-7C; MALS-3; LIN-7-C; AI303698; AU019331; AW125731; D2Ertd520e; 9130007B12Rik
• NCBI Protein Information: protein lin-7 homolog C; mLin7C; veli-3; lin 7 homolog c; vertebrate lin-7 homolog 3; mammalian lin-seven protein 3; vertebrate homolog of C. elegans Lin-7 type 3
• UniProt Protein Name: Protein lin-7 homolog C
• Protein Family: Protein
• UniProt Gene Name: Lin7c
• UniProt Synonym Gene Names: Mals3; Veli3; Lin-7C; mLin7C; MALS-3; Veli-3
• UniProt Entry Name: LIN7C_MOUSE

Uniprot Description

LIN7C: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Cell adhesion

Cellular Component: postsynaptic membrane; neuron projection; tight junction; membrane; cell; basolateral plasma membrane; cytoplasm; plasma membrane; synapse; intercellular junction; cell junction

Molecular Function: protein domain specific binding; protein binding; cytoskeletal protein binding; PDZ domain binding

Biological Process: asymmetric protein localization; protein transport; exocytosis; transport; neurotransmitter secretion; morphogenesis of an epithelial sheet; maintenance of epithelial cell polarity