Western Blot (WB)
(Western blot analysis of bovine brain tissue extract, probed with PSD-95, mAb (7E3-1B8).)
Mouse PSD-95 Monoclonal Antibody | anti-PSD-95 antibody
PSD-95 monoclonal antibody (7E3-1B8)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~95kDa by Western blot.
Western Blot (WB)
(Western blot analysis of bovine brain tissue extract, probed with PSD-95, mAb (7E3-1B8).)
Western Blot (WB)
(Western blot analysis of bovine brain tissue extract, probed with PSD-95, mAb (7E3-1B8).)
NCBI and Uniprot Product Information
Uniprot Description
PSD-95: a membrane associated guanylate kinase (MAGUK) scaffolding protein located in neural postsynaptic densities. Associates with NMDA receptor NR2 subunits via glutamate serine (aspartate/glutamate) valine motifs in the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Its overexpression or depletion changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. Binds tissue-type plasminogen activator (tPA), mediating neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. Interacts through its first two PDZ domains with NMDAR2A, NMDAR2B, NMDAR2C, NMDAR2D, ACCN3, certain splice forms of NMDAR1, KV4.2, CXADR and synGAP. Interacts through its first two PDZ domains with Kv1.1, Kv1.2, Kv1.3, Kv1.4 and HER4. Interacts through its first PDZ domain with GluR6 and Kv1.4. Interacts through its second PDZ domain with the PDZ domain of nNOS or the C-terminus of NOS1AP. May interact with 5-HT(2A). Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with SAPAP1, SAPAP2, SAPAP3, SAPAP4, MAP1A, and BEGAIN. Interacts through its guanylate kinase-like domain with KIF13B. Two alternatively spliced human isoforms have been reported. Palmitoylation of isoform 1 is required for targeting to postsynaptic density.
Protein type: Adaptor/scaffold
Cellular Component: basolateral plasma membrane; cell junction; cell projection; cortical cytoskeleton; cytoplasm; cytosol; dendrite; dendrite cytoplasm; dendritic spine; endoplasmic reticulum; excitatory synapse; extrinsic to internal side of plasma membrane; ionotropic glutamate receptor complex; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic vesicle; voltage-gated potassium channel complex
Molecular Function: acetylcholine receptor binding; beta-1 adrenergic receptor binding; D1 dopamine receptor binding; glutamate receptor binding; guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; neurexin binding; P2Y1 nucleotide receptor binding; PDZ domain binding; protein binding; protein C-terminus binding; protein complex binding; protein kinase binding; protein phosphatase binding; receptor binding; structural molecule activity
Biological Process: elevation of cytosolic calcium ion concentration; establishment and/or maintenance of epithelial cell polarity; establishment of protein localization; locomotory behavior; negative regulation of receptor internalization; neuromuscular process controlling balance; positive regulation of synaptic transmission; protein complex assembly; receptor clustering; regulation of long-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity; response to cocaine; social behavior; synaptic transmission; synaptic vesicle maturation
Research Articles on PSD-95
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Product Notes
The PSD-95 dlg4 (Catalog #AAA565148) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PSD-95 monoclonal antibody (7E3-1B8) reacts with Mouse, Rat, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's PSD-95 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Detects a band of ~95kDa by Western blot. Researchers should empirically determine the suitability of the PSD-95 dlg4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PSD-95, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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