Western Blot (WB)
(All lanes: Poly(A)-specific ribonuclease PARN antibody at 2ug/ml)
Rabbit anti-Human Poly(A)-specific ribonuclease PARN Polyclonal Antibody | anti-PARN antibody
Poly(A)-specific ribonuclease PARN Polyclonal Antibody
Immunohistochemistry: 1:20 - 1:200
Western Blot (WB)
(All lanes: Poly(A)-specific ribonuclease PARN antibody at 2ug/ml)
Western Blot (WB)
(All lanes: Poly(A)-specific ribonuclease PARN antibody at 2ug/ml)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human prostate using at dilution of 1:50.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human prostate using at dilution of 1:50.)
NCBI and Uniprot Product Information
Uniprot Description
PARN: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Homodimer. Interacts with KHSRP and CELF1/CUGBP1. Found in a mRNA decay complex with RENT1, RENT2 and RENT3B. Ubiquitous. Belongs to the CAF1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.13.4; Nucleolus; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 16p13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: cation binding; mRNA 3'-UTR binding; nuclease activity; poly(A)-specific ribonuclease activity; protein binding; protein kinase binding
Biological Process: female gamete generation; mRNA catabolic process, nonsense-mediated decay; poly(A) tail shortening; regulation of mRNA stability; RNA modification
Disease: Dyskeratosis Congenita, Autosomal Recessive, 6; Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 4
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Product Notes
The PARN parn (Catalog #AAA9416404) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Poly(A)-specific ribonuclease PARN Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Poly(A)-specific ribonuclease PARN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: 1:500 - 1:1000 Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the PARN parn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Poly(A)-specific ribonuclease PARN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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