Rabbit anti-Human POLD4 Polyclonal Antibody | anti-POLD4 antibody

POLD4 Polyclonal Antibody

Cat. Num. AAA2541031

• Gene Names: POLD4; p12; POLDS
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: POLD4; Polyclonal Antibody; POLD4 Polyclonal Antibody; POLDS;p12; anti-POLD4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 34

• Applicable Applications for anti-POLD4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500 - 1:2000
• Immunogen: Recombinant protein of human POLD4
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20°C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of MCF-7 cells, using POLD4 Polyclonal Antibody at dilution of 1:1000.)

Related Product Information for anti-POLD4 antibody

This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 12654973
• NCBI GeneID: 57804
• Molecular Weight: 12kDa
• NCBI Official Full Name: POLD4 protein
• NCBI Official Synonym Full Names: DNA polymerase delta 4, accessory subunit
• NCBI Official Symbol: POLD4
• NCBI Official Synonym Symbols: p12; POLDS
• NCBI Protein Information: DNA polymerase delta subunit 4
• UniProt Protein Name: DNA polymerase delta subunit 4
• UniProt Gene Name: POLD4
• UniProt Synonym Gene Names: POLDS
• UniProt Entry Name: DPOD4_HUMAN

NCBI Description

This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Description

POLD4: Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta. Belongs to the DNA polymerase delta subunit 4 family.

Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: delta DNA polymerase complex; nucleoplasm; nucleus

Molecular Function: DNA-directed DNA polymerase activity; protein binding

Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA replication; DNA strand elongation during DNA replication; DNA synthesis during DNA repair; DNA-dependent DNA replication; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair