Western Blot (WB)
(PNKD Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PNKD antibody detected the PNKD protein (arrow).)
Rabbit anti-Mouse PNKD Polyclonal Antibody | anti-PNKD antibody
PNKD, NT (PNKD, KIAA1184, MR1, TAHCCP2, Probable hydrolase PNKD, Myofibrillogenesis regulator 1, Paroxysmal nonkinesiogenic dyskinesia protein, Trans-activated by hepatitis C virus core protein 2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50
Western Blot (WB)
(PNKD Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PNKD antibody detected the PNKD protein (arrow).)
Western Blot (WB)
(PNKD Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PNKD antibody detected the PNKD protein (arrow).)
Immunohistochemistry (IHC)
(PNKD Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PNKD Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(PNKD Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PNKD Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Description
Function: Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway
By similarity.
Subunit structure: Isoform 2 interacts with the sarcomeric proteins, MRLC2, MYOM1 and ENO3. Ref.1
Subcellular location: Isoform 1: Membrane; Peripheral membrane protein. Isoform 2: Cytoplasm. Nucleus. Isoform 3: Mitochondrion.
Tissue specificity: Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only. Ref.1 Ref.15 Ref.16
Induction: By Hepatitis C virus core protein. Ref.2
Post-translational modification: Isoform 2 is phosphorylated at Ser-121 upon DNA damage, probably by ATM or ATR.
Involvement in disease: Dystonia 8 (DYT8) [MIM:118800]: A paroxysmal non-kinesigenic dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 8 is characterized by attacks of involuntary movements brought on by stress, alcohol, fatigue or caffeine. The attacks generally last between a few seconds and four hours or longer. The attacks may begin in one limb and spread throughout the body, including the face.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11 Ref.15 Ref.17 Ref.18 Ref.19
Sequence similarities: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Research Articles on PNKD
Similar Products
Product Notes
The PNKD pnkd (Catalog #AAA645815) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PNKD, NT (PNKD, KIAA1184, MR1, TAHCCP2, Probable hydrolase PNKD, Myofibrillogenesis regulator 1, Paroxysmal nonkinesiogenic dyskinesia protein, Trans-activated by hepatitis C virus core protein 2) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PNKD can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot, Immunohistochemistry, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50. Researchers should empirically determine the suitability of the PNKD pnkd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PNKD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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