Western Blot (WB)
(Western Blot analysis of extracts of various cells, using PIP4K2B antibody.)
Rabbit PIP4K2B Polyclonal Antibody | anti-PIP4K2B antibody
PIP4K2B Polyclonal Antibody
IF: 1:50-1:100
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of various cells, using PIP4K2B antibody.)
Western Blot (WB)
(Western Blot analysis of extracts of various cells, using PIP4K2B antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat brain using PIP4K2B antibody at dilution of 1:100 (x40 lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat brain using PIP4K2B antibody at dilution of 1:100 (x40 lens).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
Uniprot Description
PIP4K2B: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.1.149; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; plasma membrane; cytosol
Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; receptor signaling protein activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding
Biological Process: cell surface receptor linked signal transduction; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process
Research Articles on PIP4K2B
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Product Notes
The PIP4K2B pip4k2b (Catalog #AAA3009006) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PIP4K2B Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PIP4K2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:500-1:2000 IF: 1:50-1:100. Researchers should empirically determine the suitability of the PIP4K2B pip4k2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PIP4K2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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