Rabbit anti-Human, Mouse TRIM41 Polyclonal Antibody | anti-TRIM41 antibody

TRIM41, CT (TRIM41, RINCK, E3 ubiquitin-protein ligase TRIM41, RING finger-interacting protein with C kinase, Tripartite motif-containing protein 41) (Azide free) (HRP)

Cat. Num. AAA6358389

• Gene Names: TRIM41; RINCK
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TRIM41; Polyclonal Antibody; CT (TRIM41; RINCK; E3 ubiquitin-protein ligase TRIM41; RING finger-interacting protein with C kinase; Tripartite motif-containing protein 41) (Azide free) (HRP); Tripartite motif-containing protein 41; anti-TRIM41 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 518

• Applicable Applications for anti-TRIM41 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TRIM41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-596 amino acids from the C-terminal region of human TRIM41.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TRIM41 Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the TRIM41 antibody detected the TRIM41 protein (arrow).)

Related Product Information for anti-TRIM41 antibody

TRIM41 belongs to a family of tripartite motif (TRIM) proteins defined as containing a RING finger, one or more B-box domains, and a coiled-coil region (Tanaka et al., 2005 [PubMed 16022281]). See TRIM45 (MIM 609318).

Product Categories/Family for anti-TRIM41 antibody

Antibodies; Transcription Factors; TRIM (Tripartite Motif)

References

Chen, D., et al. J. Biol. Chem. 282(46):33776-33787(2007). Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006). Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006). Tanaka, M., et al. Mol. Biol. Rep. 32(2):87-93(2005). Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 42516574
• NCBI GeneID: 90933
• NCBI Accession #: NP_963921.1; NP_291027.3
• NCBI GenBank Nucleotide #: NP_963921.1
• UniProt Accession #: Q8WV44
• NCBI Official Full Name: E3 ubiquitin-protein ligase TRIM41 isoform 2
• NCBI Official Synonym Full Names: tripartite motif containing 41
• NCBI Official Symbol: TRIM41
• NCBI Official Synonym Symbols: RINCK
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM41
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM41
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: TRIM41
• UniProt Synonym Gene Names: RINCK; RINCK
• UniProt Entry Name: TRI41_HUMAN

NCBI Description

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

TRIM41: Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. Belongs to the TRIM/RBCC family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: cytoplasm; nucleolus

Molecular Function: protein binding; zinc ion binding; ligase activity

Biological Process: protein ubiquitination