Western Blot (WB)
(Western Blot: Sample: Human Raji Cells.)
Rabbit anti-Human Phospholipase C Gamma 2 Polyclonal Antibody | anti-PLCg2 antibody
Polyclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Human Raji Cells.)
Western Blot (WB)
(Western Blot: Sample: Human Raji Cells.)
Western Blot (WB)
(Western Blot: Sample: Recombinant PLCg2, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant PLCg2, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
Uniprot Description
PLCG2: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 16q23.3
Cellular Component: cytosol; extracellular exosome; plasma membrane
Molecular Function: phosphoinositide phospholipase C activity; phospholipase C activity; phosphotyrosine binding; protein binding; signal transducer activity
Biological Process: activation of store-operated calcium channel activity; B cell differentiation; B cell receptor signaling pathway; calcium-mediated signaling; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; follicular B cell differentiation; inositol phosphate metabolic process; inositol trisphosphate biosynthetic process; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; phospholipid catabolic process; platelet activation; positive regulation of interferon type I production; positive regulation of receptor internalization; regulation of gene expression; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; Wnt signaling pathway
Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3
Research Articles on PLCg2
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Product Notes
The PLCg2 plcg2 (Catalog #AAA2027774) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Phospholipase C Gamma 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the PLCg2 plcg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospholipase C Gamma 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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