Flow Cytometry (FC/FACS)
(C57BL/6 murine splenocytes are stained with Anti-Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.)
Rat anti-Mouse CD103 Monoclonal Antibody | anti-CD103 antibody
Anti-Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated)
Gene Names
Itgae; CD103; aM290; alpha-E1; A530055J10; alpha-M290
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Synonyms
CD103; Monoclonal Antibody; Anti-Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated); Integrin alpha-E; Itgae; Integrin alpha M290; anti-CD103 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
M290
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Sequence Length
1,167
Applicable Applications for anti-CD103 antibody
Flow Cytometry (FC/FACS)
Conjugation
Alexa Fluor 488
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
Flow Cytometry (FC/FACS)
(C57BL/6 murine splenocytes are stained with Anti-Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.)
Flow Cytometry (FC/FACS)
(C57BL/6 murine splenocytes are stained with Anti-Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.)
Related Product Information for anti-CD103 antibody
CD103 is a type I transmembrane glycoprotein known as alphaE integrin or Integrin alphaIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-beta stimulation. In association with integrin beta7, CD103 is expressed as alphaE/beta7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
References
1. Kilshaw PJ and SJ. Murant. 1990. Eur. J. Immunol. 20:2201. 2. Karecla PI, et al. 1995. Eur. J. Immunol. 25:852. 3. LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635. 4. Sung SS, et al. 2006. J. Immunol. 176:2161. 5. Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063. 6. Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
128,906 Da
NCBI Official Full Name
integrin alpha-E isoform 1
NCBI Official Synonym Full Names
integrin alpha E, epithelial-associated
NCBI Official Symbol
Itgae
NCBI Official Synonym Symbols
CD103; aM290; alpha-E1; A530055J10; alpha-M290
NCBI Protein Information
integrin alpha-E
UniProt Protein Name
Integrin alpha-E
UniProt Gene Name
Itgae
Uniprot Description
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.
Research Articles on CD103
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Product Notes
The CD103 itgae (Catalog #AAA2556522) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD103 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CD103 itgae for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD103, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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