Western Blot (WB)
(Western Blot analysis: Bovine cardiac preparation, treated with PKA (lane 1) or untreated (lane 2), was probed with MBS617405 (0.5ug/ml).)
Rabbit Phospholamban Polyclonal Antibody | anti-PLN antibody
Phospholamban, Phosphorylated (Ser16) (AP)
WB: 0.5-2ug/ml detects phosphorylated phospholamban from a bovine cardiac preparation that was incubated with. Proteins were visualized using an IgG (HRP) goat anti-rabbit and a chemiluminescence detection system.
Western Blot (WB)
(Western Blot analysis: Bovine cardiac preparation, treated with PKA (lane 1) or untreated (lane 2), was probed with MBS617405 (0.5ug/ml).)
Western Blot (WB)
(Western Blot analysis: Bovine cardiac preparation, treated with PKA (lane 1) or untreated (lane 2), was probed with MBS617405 (0.5ug/ml).)
NCBI and Uniprot Product Information
Uniprot Description
PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
Protein type: Membrane protein, integral; Inhibitor
Chromosomal Location of Human Ortholog: 6q22.1
Cellular Component: sarcoplasmic reticulum membrane; mitochondrion; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; mitochondrial membrane; vesicle
Molecular Function: enzyme inhibitor activity; identical protein binding; protein binding; ATPase inhibitor activity; calcium channel regulator activity; ATPase binding
Biological Process: cardiac muscle development; negative regulation of calcium ion transport; negative regulation of heart rate; cytosolic calcium ion homeostasis; blood circulation; regulation of calcium ion transport; response to testosterone stimulus; regulation of heart contraction; response to insulin stimulus; response to zinc ion; calcium ion transport; negative regulation of catalytic activity; negative regulation of ATPase activity; regulation of the force of heart contraction; protein homooligomerization
Disease: Cardiomyopathy, Dilated, 1p; Cardiomyopathy, Familial Hypertrophic, 18
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Product Notes
The PLN pln (Catalog #AAA6493254) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospholamban, Phosphorylated (Ser16) (AP) reacts with Human, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's Phospholamban can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. WB: 0.5-2ug/ml detects phosphorylated phospholamban from a bovine cardiac preparation that was incubated with. Proteins were visualized using an IgG (HRP) goat anti-rabbit and a chemiluminescence detection system. Researchers should empirically determine the suitability of the PLN pln for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospholamban, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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