Western Blot (WB)
(PHF21A Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PHF21A antibody detected the PHF21A protein (arrow).)
Rabbit PHF21A Polyclonal Antibody | anti-PHF21A antibody
PHF21A Antibody (Center)
Western Blot (WB)
(PHF21A Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PHF21A antibody detected the PHF21A protein (arrow).)
Western Blot (WB)
(PHF21A Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PHF21A antibody detected the PHF21A protein (arrow).)
(MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex
(BHC) that mediates repression of neuron-specific genes through the
cis-regulatory element known as repressor element-1 (RE1) or neural
restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed
12032298]).
Klajn, A., et al. J. Neurosci. 29(19):6296-6307(2009)
Hailesellasse Sene, K., et al. BMC Genomics 8, 85 (2007) :
Shi, Y.J., et al. Mol. Cell 19(6):857-864(2005)
Iwase, S., et al. Biochem. Biophys. Res. Commun. 322(2):601-608(2004)
NCBI and Uniprot Product Information
NCBI Description
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Uniprot Description
PHF21A: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: nucleoplasm; histone deacetylase complex
Molecular Function: DNA binding; zinc ion binding; chromatin binding
Biological Process: establishment and/or maintenance of chromatin architecture; suckling behavior; transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; blood coagulation
Research Articles on PHF21A
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Product Notes
The PHF21A phf21a (Catalog #AAA9206820) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 436-464. The PHF21A Antibody (Center) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PHF21A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PHF21A phf21a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PHF21A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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