Western Blot (WB)
(PHEX Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PHEX antibody detected the PHEX protein (arrow).)
Rabbit PHEX Polyclonal Antibody | anti-PHEX antibody
PHEX Antibody (C-term)
Western Blot (WB)
(PHEX Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PHEX antibody detected the PHEX protein (arrow).)
Western Blot (WB)
(PHEX Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PHEX antibody detected the PHEX protein (arrow).)
endopeptidase that belongs to the type II integral membrane
zinc-dependent endopeptidase family. The protein is thought to be
involved in bone and dentin mineralization and renal phosphate
reabsorption. Mutations in this gene cause X-linked
hypophosphatemic rickets.
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Clausmeyer, S., et al. Calcif. Tissue Int. 85(3):211-220(2009)
Gaucher, C., et al. Hum. Genet. 125(4):401-411(2009)
Strom, T.M., et al. Curr. Opin. Nephrol. Hypertens. 17(4):357-362(2008)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Description
PHEX: Probably involved in bone and dentin mineralization and renal phosphate reabsorption. Defects in PHEX are a cause of hypophosphatemic rickets, X-linked dominant (XLHR). XLHR is an X-linked dominant disorder characterized by impaired phosphate uptake in the kidney, which is likely to be caused by abnormal regulation of sodium phosphate cotransport in the proximal tubules. Clinical manifestations include skeletal deformities, growth failure, craniosynostosis, paravertebral calcifications, pseudofractures in lower extremities, and muscular hypotonia with onset in early childhood. X-linked hypophosphatemic rickets is the most common form of hypophosphatemia with an incidence of 1 in 20000. Belongs to the peptidase M13 family.
Protein type: Protease; EC 3.4.24.-; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.2-p22.1
Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to plasma membrane; endoplasmic reticulum; plasma membrane
Molecular Function: zinc ion binding; metalloendopeptidase activity; aminopeptidase activity
Biological Process: cell-cell signaling; protein modification process; organophosphate metabolic process; proteolysis; skeletal development; bone mineralization
Disease: Hypophosphatemic Rickets, X-linked Dominant
Research Articles on PHEX
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Product Notes
The PHEX phex (Catalog #AAA9202766) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 567-595. The PHEX Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PHEX can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PHEX phex for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PHEX, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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