Western Blot (WB)
(Western blot analysis of anti-PFKFB2 Pab in mouse kidney tissue lysate (35ug/lane). PFKFB2(arrow) was detected using the purified Pab)
Rabbit anti-Human PFKFB2 Polyclonal Antibody | anti-PFKFB2 antibody
PFKFB2 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of anti-PFKFB2 Pab in mouse kidney tissue lysate (35ug/lane). PFKFB2(arrow) was detected using the purified Pab)
Western Blot (WB)
(Western blot analysis of anti-PFKFB2 Pab in mouse kidney tissue lysate (35ug/lane). PFKFB2(arrow) was detected using the purified Pab)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Heine-Suner, D., et al., Eur. J. Biochem. 254(1):103-110 (1998).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PFKFB2: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - fructose and mannose; Phosphatase (non-protein); Kinase, other; EC 3.1.3.46; EC 2.7.1.105
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytosol
Molecular Function: protein binding; fructose-2,6-bisphosphate 2-phosphatase activity; 6-phosphofructo-2-kinase activity; protein kinase binding; ATP binding
Biological Process: glycolysis; glucose metabolic process; positive regulation of insulin secretion; pathogenesis; fructose 2,6-bisphosphate metabolic process; glucose catabolic process; dephosphorylation; carbohydrate phosphorylation; carbohydrate metabolic process; lactate metabolic process; response to glucose stimulus; fructose metabolic process; positive regulation of glucokinase activity
Research Articles on PFKFB2
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Product Notes
The PFKFB2 pfkfb2 (Catalog #AAA9206409) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The PFKFB2 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PFKFB2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the PFKFB2 pfkfb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PFKFB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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