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Western Blot (WB) (Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Hepg2 cells, HT29 cells, Primary antibody: 820733(KCNH6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)

Rabbit anti-Human ERG2 Polyclonal Antibody | anti-ERG2 antibody

ERG2 Rabbit pAb

Gene Names
KCNH6; ERG2; ERG-2; HERG2; Kv11.2; hERG-2
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity purified
Synonyms
ERG2; Polyclonal Antibody; ERG2 Rabbit pAb; ERG-2; HERG2; Kv11.2; hERG-2; anti-ERG2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Purity/Purification
Affinity purified
Form/Format
-20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Applicable Applications for anti-ERG2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
WB: 1:200-1:1000
Immunogen
Fusion protein of human KCNH6
Conjugation
Unconjugated
Molecular Function
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms.
Modification
Unmodified
Cell Position
Membrane
Preparation and Storage
Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Hepg2 cells, HT29 cells, Primary antibody: 820733(KCNH6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)

Western Blot (WB) (Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Hepg2 cells, HT29 cells, Primary antibody: 820733(KCNH6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 820733(KCNH6 Antibody) at dilution 1/30. (Original magnification: ×200))

Immunohistochemistry (IHC) (The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 820733(KCNH6 Antibody) at dilution 1/30. (Original magnification: ×200))
Product Categories/Family for anti-ERG2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
56,298 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 6, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily H member 6
NCBI Official Symbol
KCNH6
NCBI Official Synonym Symbols
ERG2; ERG-2; HERG2; Kv11.2; hERG-2
NCBI Protein Information
potassium voltage-gated channel subfamily H member 6
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 6
Protein Family
UniProt Gene Name
KCNH6
UniProt Synonym Gene Names
ERG2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Description

Kv11.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: voltage-gated potassium channel activity

Biological Process: regulation of membrane potential

Research Articles on ERG2

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Product Notes

The ERG2 kcnh6 (Catalog #AAA4757805) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERG2 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERG2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:200-1:1000. Researchers should empirically determine the suitability of the ERG2 kcnh6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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