Western Blot (WB)
(Western Blot analysis of 3T3 cells using Phospho-Per2 (S662) Polyclonal Antibody)
Rabbit anti-Human, Mouse PER2 Polyclonal Antibody | anti-PER2 antibody
Phospho-PER2 (S662) Antibody
IHC: 1:100-1:300
ELISA: 1:5000
Western Blot (WB)
(Western Blot analysis of 3T3 cells using Phospho-Per2 (S662) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 3T3 cells using Phospho-Per2 (S662) Polyclonal Antibody)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]
Uniprot Description
PER2: a transcription factor belonging to the basic helix-loop-helix (bHLH) family. A member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hr rhythm in the suprachiasmatic nucleus and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between per1 and per2 oscillations. The expression rhythms appear to originate from retina.
Protein type: Nucleolus; Transcription factor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: ubiquitin binding; signal transducer activity; protein binding; histone deacetylase binding; transcription coactivator activity; kinase binding; nuclear hormone receptor binding
Biological Process: circadian rhythm; glycogen biosynthetic process; transcription, DNA-dependent; regulation of cell cycle; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; regulation of circadian rhythm; signal transduction; regulation of glutamate uptake during transmission of nerve impulse; gluconeogenesis; regulation of neurogenesis; regulation of vasoconstriction; white fat cell differentiation; lactate biosynthetic process; negative regulation of protein ubiquitination; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of insulin secretion
Disease: Advanced Sleep Phase Syndrome, Familial, 1
Research Articles on PER2
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Product Notes
The PER2 per2 (Catalog #AAA7118698) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-PER2 (S662) Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PER2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500-1:2000 IHC: 1:100-1:300 ELISA: 1:5000. Researchers should empirically determine the suitability of the PER2 per2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PER2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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