Western Blot (WB)
(Western blot analysis of extracts from COS cells treated with TNF using PEA-15 (Phospho-Ser104) Antibody.The lane on the right is treated with the antigen-specific peptide.)
Rabbit PEA-15 Polyclonal Antibody | anti-PEA-15 antibody
PEA-15 (Phospho-Ser104) Antibody
Immunohistochemistry: 1:50~1:100
Western Blot (WB)
(Western blot analysis of extracts from COS cells treated with TNF using PEA-15 (Phospho-Ser104) Antibody.The lane on the right is treated with the antigen-specific peptide.)
Western Blot (WB)
(Western blot analysis of extracts from COS cells treated with TNF using PEA-15 (Phospho-Ser104) Antibody.The lane on the right is treated with the antigen-specific peptide.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human heart tissue using PEA-15 (Phospho-Ser104) antibody (left)or the same antibody preincubated with blocking peptide (right).)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human heart tissue using PEA-15 (Phospho-Ser104) antibody (left)or the same antibody preincubated with blocking peptide (right).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
PEA-15: an ubiquitously expressed anti-apoptotic protein. Inhibits both Fas- and Tnfrsf1a/Tnfr1-mediated caspase-8 activity and apoptosis. Interacts with CASP8/FLICE and FADD. Regulates glucose transport by controlling both the content of GLUT1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of GLUT4 from the cell interior to the surface. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
Protein type: Apoptosis; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q21.1
Cellular Component: microtubule associated complex; cytoplasm
Molecular Function: protein binding
Biological Process: negative regulation of glucose import; transport; apoptosis; DNA damage checkpoint; carbohydrate transport; response to morphine
Research Articles on PEA-15
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Product Notes
The PEA-15 pea15 (Catalog #AAA9407381) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PEA-15 (Phospho-Ser104) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PEA-15 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the PEA-15 pea15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PEA-15, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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