Rabbit anti-Human PDLIM2 Polyclonal Antibody | anti-PDLIM2 antibody

PDLIM2 Antibody

Cat. Num. AAA7053185

• Gene Names: PDLIM2; SLIM; MYSTIQUE
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G purified
• Synonyms: PDLIM2; Polyclonal Antibody; PDLIM2 Antibody; PDZ and LIM domain protein 2; PDZ-LIM protein mystique; PP6345; anti-PDLIM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 602

• Applicable Applications for anti-PDLIM2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:20-1:200
• Immunogen: Recombinant Human PDZ and LIM domain protein 2 protein (161-284AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7053185 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7053185 at dilution of 1:100)

Related Product Information for anti-PDLIM2 antibody

Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.

NCBI and Uniprot Product Information

• NCBI GI #: 311771772
• NCBI GeneID: 64236
• NCBI Accession #: NP_067643.3
• NCBI GenBank Nucleotide #: NM_021630.5
• UniProt Accession #: Q96JY6; Q7Z584; Q86WM8; Q8WZ29; Q9H4L9; Q9H7I2; D3DSR5; J3KNH4
• Molecular Weight: 62,746 Da
• NCBI Official Full Name: PDZ and LIM domain protein 2 isoform 2
• NCBI Official Synonym Full Names: PDZ and LIM domain 2
• NCBI Official Symbol: PDLIM2
• NCBI Official Synonym Symbols: SLIM; MYSTIQUE
• NCBI Protein Information: PDZ and LIM domain protein 2
• UniProt Protein Name: PDZ and LIM domain protein 2
• Protein Family: PDZ and LIM domain protein
• UniProt Gene Name: PDLIM2

NCBI Description

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

PDLIM2: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: actin cytoskeleton; focal adhesion

Molecular Function: protein binding