Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded section of Human Placenta Tissue)
Rabbit PDIA3 Polyclonal Antibody | anti-PDIA3 antibody
PDIA3 Antibody
Gene Names
PDIA3; P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n
Applications
Western Blot, Immunohistochemistry
Purity
Affinity Chromatography
Synonyms
PDIA3; Polyclonal Antibody; PDIA3 Antibody; Affinity Purified Rabbit Polyclonal PDIA3 Antibody; Polyclonal PDIA3 antibody; Anti-PDIA3 antibody; PDIA 3 antibody; GRP58 antibody; PDIA 3; ER60 antibody; Erp57 antibody; PDIA-3; PDIA-3 antibody; Protein disulfide isomerase family A member 3 antibody; anti-PDIA3 antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Lyophilized Form
Sequence Length
505
Applicable Applications for anti-PDIA3 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Immunogen
PDIA3 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle region of human PDIA3, identical to the related rat and Rabbit sequences, as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded section of Human Placenta Tissue)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded section of Human Placenta Tissue)
Western Blot (WB)
(Lane 1: SMMC Cell Lysate; Lane 2: A549 Cell Lysate; Lane 3: U87 Cell Lysate; Lane 4: HELA Cell Lysate; Lane 5: MCF-7 Cell Lysate)
Western Blot (WB)
(Lane 1: SMMC Cell Lysate; Lane 2: A549 Cell Lysate; Lane 3: U87 Cell Lysate; Lane 4: HELA Cell Lysate; Lane 5: MCF-7 Cell Lysate)
Related Product Information for anti-PDIA3 antibody
PDIA3 is an isomerase enzyme, mapped on 15q15.3. The PDIA3 protein has protein disulfide isomerase activity. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex, which is essential for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface. Koivunen et al. showed that PDIA3 could not substitute for the beta subunit of PDI. When coexpressed with alpha prolyl 4-hydroxylase, PDIA3 did not form prolyl 4-hydroxylase tetramers, nor did it have prolyl 4-hydroxylase activity. Hirano et al. expressed human PDIA3 and found that the protein had a thiol-dependent reductase activity. They showed that the expression level of PDIA3 is increased after oncogenic transformation of normal rat kidney cells and NIH 3T3 cells.
Product Categories/Family for anti-PDIA3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
protein disulfide-isomerase A3
NCBI Official Synonym Full Names
protein disulfide isomerase family A member 3
NCBI Official Symbol
PDIA3
NCBI Official Synonym Symbols
P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n
NCBI Protein Information
protein disulfide-isomerase A3
UniProt Protein Name
Protein disulfide-isomerase A3
Protein Family
UniProt Gene Name
PDIA3
UniProt Synonym Gene Names
ERP57; ERP60; GRP58; p58; ER protein 57; ERp57; ER protein 60; ERp60
UniProt Entry Name
PDIA3_HUMAN
NCBI Description
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]
Research Articles on PDIA3
Similar Products
Product Notes
The PDIA3 pdia3 (Catalog #AAA5312973) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PDIA3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the PDIA3 pdia3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDIA3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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