Western Blot (WB)
(Western Blot analysis of various cells using NOS1 Polyclonal Antibody at dilution of 1:500.)
Rabbit NOS1 Polyclonal Antibody | anti-NOS1 antibody
NOS1 Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of various cells using NOS1 Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of various cells using NOS1 Polyclonal Antibody at dilution of 1:500.)
NCBI and Uniprot Product Information
Observed MW: 120
NCBI Description
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Description
nNOS: nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described.
Protein type: Oxidoreductase; Amino Acid Metabolism - arginine and proline; EC 1.14.13.39
Chromosomal Location of Human Ortholog: 12q24.22
Cellular Component: azurophil granule; caveola; cytoplasm; cytoskeleton; cytosol; dendritic spine; lipid raft; mitochondrial outer membrane; mitochondrion; nuclear membrane; perinuclear region of cytoplasm; photoreceptor inner segment; postsynaptic density; protein complex; sarcolemma; sarcoplasmic reticulum; synapse; T-tubule; vesicle membrane; Z disc
Molecular Function: cadmium ion binding; calmodulin binding; enzyme binding; FAD binding; FMN binding; heme binding; iron ion binding; NADP binding; nitric-oxide synthase activity; protein binding; protein homodimerization activity; sodium channel regulator activity
Biological Process: aging; arginine catabolic process; behavioral response to cocaine; blood coagulation; cell redox homeostasis; exogenous drug catabolic process; female pregnancy; multicellular organismal response to stress; myoblast fusion; negative regulation of apoptosis; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of cell proliferation; negative regulation of heart contraction; negative regulation of hydrolase activity; negative regulation of insulin secretion; negative regulation of potassium ion transport; negative regulation of serotonin uptake; negative regulation of vasoconstriction; neurotransmitter biosynthetic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of guanylate cyclase activity; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; reduction of cytosolic calcium ion concentration; regulation of neurogenesis; regulation of sensory perception of pain; regulation of sodium ion transport; response to activity; response to estrogen stimulus; response to ethanol; response to heat; response to hypoxia; response to lead ion; response to lipopolysaccharide; response to nicotine; response to peptide hormone stimulus; response to vitamin E; striated muscle contraction
Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
Research Articles on NOS1
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Product Notes
The NOS1 nos1 (Catalog #AAA2535941) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NOS1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NOS1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA). WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the NOS1 nos1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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