Western Blot (WB)
(Mouse Pdgfra Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Pdgfra antibody detected the Pdgfra protein (arrow).)
Rabbit anti-Mouse Pdgfra Polyclonal Antibody | anti-Pdgfra antibody
Mouse Pdgfra Antibody (Center)
Western Blot (WB)
(Mouse Pdgfra Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Pdgfra antibody detected the Pdgfra protein (arrow).)
Western Blot (WB)
(Mouse Pdgfra Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Pdgfra antibody detected the Pdgfra protein (arrow).)
Bardsley, M.R., et al. Gastroenterology 139(3):942-952(2010)
Bax, N.A., et al. Dev. Dyn. 239(8):2307-2317(2010)
Lei, H., et al. Am. J. Pathol. 177(1):132-140(2010)
Zheng, K., et al. J. Neurosci. 30(24):8245-8250(2010)
NCBI and Uniprot Product Information
Uniprot Description
PDGFRA: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described.
Protein type: Protein kinase, TK; Oncoprotein; EC 2.7.10.1; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; PDGFR family
Cellular Component: cell surface; microvillus; membrane; integral to plasma membrane; cytoplasm; plasma membrane; integral to membrane; cytosol; nucleus; intrinsic to plasma membrane; external side of plasma membrane
Molecular Function: protein homodimerization activity; platelet-derived growth factor binding; nucleotide binding; platelet-derived growth factor receptor binding; platelet-derived growth factor alpha-receptor activity; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; vascular endothelial growth factor receptor activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein complex binding; phosphoinositide 3-kinase binding; kinase activity; ATP binding
Biological Process: estrogen metabolic process; extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of chemotaxis; wound healing; multicellular organismal development; protein amino acid autophosphorylation; cardiac myofibril assembly; platelet-derived growth factor receptor signaling pathway; palate development; chemotaxis; protein amino acid phosphorylation; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; Leydig cell differentiation; embryonic digestive tract morphogenesis; luteinization; positive regulation of cell proliferation; male genitalia development; female gonad development; anatomical structure morphogenesis; cell migration; phosphoinositide-mediated signaling; adrenal gland development; in utero embryonic development; positive regulation of phosphoinositide 3-kinase activity; embryonic cranial skeleton morphogenesis; odontogenesis of dentine-containing teeth; organ morphogenesis; skeletal morphogenesis; hemopoietic progenitor cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of DNA replication; positive regulation of cell migration; lung development
Research Articles on Pdgfra
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Product Notes
The Pdgfra pdgfra (Catalog #AAA9209516) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 678-706. The Mouse Pdgfra Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Pdgfra can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Pdgfra pdgfra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pdgfra, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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