Rabbit PDE7B Polyclonal Antibody | anti-PDE7B antibody

Rabbit Polyclonal to Human PDE7B

Cat. Num. AAA240107

• Gene Names: PDE7B; bA472E5.1
• Reactivity: Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PDE7B; Polyclonal Antibody; Rabbit Polyclonal to Human PDE7B; Anti-PDE7B Antibody (N-Terminus) IHC-plus; BA472E5.1; Phosphodiesterase 7B; Human PDE7B; anti-PDE7B antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PDE7B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 450

• Applicable Applications for anti-PDE7B antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from near N-terminus of human PDE7B. Percent identity with other species by BLAST analysis: Human (100%); Gibbon, Monkey (94%); Gorilla, Mouse, Rat, Elephant, Horse, Rabbit (88%); Opossum (82%).
• Immunogen Type: Synthetic peptide
• Immunogen: PDE7B antibody was raised against synthetic 17 amino acid peptide from near N-terminus of human PDE7B. Percent identity with other species by BLAST analysis: Human (100%); Gibbon, Monkey (94%); Gorilla, Mouse, Rat, Elephant, Horse, Rabbit (88%); Opossum (82%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PDE7B antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-PDE7B antibody

Phosphodiesterase 7B, a cAMP-specific phosphodiesterase, has been shown to affect cAMP-mediated neural activity and cAMP metabolism in the brain. PDE7B activity is inhibited by dipyridamole, IBMX, and SCH51866. At least three splice variants have been isolated for PDE7B from rats and they show tissue specific expression patterns.

Product Categories/Family for anti-PDE7B antibody

Family: Phosphodiesterase; Subfamily: PDE - cAMP-specific

NCBI and Uniprot Product Information

• NCBI GI #: 9506959
• NCBI GeneID: 27115
• NCBI Accession #: NP_061818.1
• NCBI GenBank Nucleotide #: NM_018945.3
• UniProt Accession #: Q9NP56; Q5W154
• Molecular Weight: 51,835 Da
• NCBI Official Full Name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B
• NCBI Official Synonym Full Names: phosphodiesterase 7B
• NCBI Official Symbol: PDE7B
• NCBI Official Synonym Symbols: bA472E5.1
• NCBI Protein Information: cAMP-specific 3',5'-cyclic phosphodiesterase 7B; rolipram-insensitive phosphodiesterase type 7; high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B
• Protein Family: cAMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE7B
• UniProt Entry Name: PDE7B_HUMAN

NCBI Description

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]

Uniprot Description

PDE7B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.

Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 6q23-q24

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding

Biological Process: synaptic transmission; cAMP catabolic process; signal transduction