Rabbit anti-Human PDE6H Polyclonal Antibody | anti-PDE6H antibody

PDE6H Antibody; Biotin conjugated

Cat. Num. AAA7003998

• Gene Names: PDE6H; RCD3; ACHM6
• Reactivity: Human
• Applications: ELISA
• Purity: >95%,Protein G purified
• Synonyms: PDE6H; Polyclonal Antibody; PDE6H Antibody; Biotin conjugated; Retinal cone rhodopsin-sensitive cGMP 3'; 5'-cyclic phosphodiesterase subunit gamma; GMP-PDE gamma; anti-PDE6H antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 83

• Applicable Applications for anti-PDE6H antibody: ELISA (EIA)
• Immunogen: Recombinant human Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma protein
• Conjugation: Biotin
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Related Product Information for anti-PDE6H antibody

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

NCBI and Uniprot Product Information

• NCBI GI #: 5453868
• NCBI GeneID: 5149
• NCBI Accession #: NP_006196.1
• NCBI GenBank Nucleotide #: NM_006205.2
• UniProt Accession #: Q13956; Q52LY7
• Molecular Weight: 9,074 Da
• NCBI Official Full Name: retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• NCBI Official Synonym Full Names: phosphodiesterase 6H
• NCBI Official Symbol: PDE6H
• NCBI Official Synonym Symbols: RCD3; ACHM6
• NCBI Protein Information: retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• UniProt Protein Name: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• Protein Family: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6H
• UniProt Synonym Gene Names: GMP-PDE gamma
• UniProt Entry Name: CNCG_HUMAN

NCBI Description

This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]

Uniprot Description

PDE6H: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Defects in PDE6H are the cause of cone dystrophy retinal type 3A (RCD3A); also known as cone dystrophy with night blindness and supernormal rod responses. RCD3A is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the rod/cone cGMP-PDE gamma subunit family.

Protein type: Nucleotide Metabolism - purine; Inhibitor; EC 3.1.4.35; Phosphodiesterase

Chromosomal Location of Human Ortholog: 12p13

Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; enzyme inhibitor activity; protein binding

Biological Process: activation of MAPK activity; metabolic process; negative regulation of catalytic activity; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; response to stimulus; visual perception

Disease: Retinal Cone Dystrophy 3a