anti-Human, Mouse PDE6G Polyclonal Antibody | anti-PDE6G antibody

PDE6G Polyclonal Antibody

Cat. Num. AAA8537586

• Gene Names: PDE6G; PDEG; RP57
• Reactivity: Human, Mouse
• Synonyms: PDE6G; Polyclonal Antibody; PDE6G Polyclonal Antibody; PDE6G PDEG; anti-PDE6G antibody

• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Form/Format: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
• Sequence Length: 87

• Immunogen: Synthesized peptide derived from human PDE6G

Related Product Information for anti-PDE6G antibody

This antibody detects endogenous levels of human PDE6G

NCBI and Uniprot Product Information

• NCBI GI #: 4505673
• NCBI GeneID: 5148
• NCBI Accession #: NP_002593.1
• NCBI GenBank Nucleotide #: NP_002593.1
• UniProt Accession #: P18545
• NCBI Official Full Name: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• NCBI Official Synonym Full Names: phosphodiesterase 6G
• NCBI Official Symbol: PDE6G
• NCBI Official Synonym Symbols: PDEG; RP57
• NCBI Protein Information: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• UniProt Protein Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• Protein Family: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6G
• UniProt Synonym Gene Names: PDEG; GMP-PDE gamma
• UniProt Entry Name: CNRG_HUMAN

NCBI Description

This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Uniprot Description

Function: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activity: Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Subunit structure: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Involvement in disease: Retinitis pigmentosa 57 (RP57) [MIM:613582]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7

Sequence similarities: Belongs to the rod/cone cGMP-PDE gamma subunit family.

Sequence caution: The sequence CAD97656.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence EAW89666.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.