Rabbit anti-Human, Mouse PDCD5 Polyclonal Antibody | anti-PDCD5 antibody

PDCD5, NT (PDCD5, TFAR19, Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19) (Biotin)

Cat. Num. AAA6332014

• Gene Names: PDCD5; TFAR19
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PDCD5; Polyclonal Antibody; NT (PDCD5; TFAR19; Programmed cell death protein 5; TF-1 cell apoptosis-related protein 19) (Biotin); TF-1 cell apoptosis-related protein 19; anti-PDCD5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-PDCD5 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PDCD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5~34 amino acids from the N-terminal region of human PDCD5.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of PDCD5 Antibody (N-term) in mouse testis tissue lysates (35ug/lane). PDCD5 (arrow) was detected using the purified Pab.)

Related Product Information for anti-PDCD5 antibody

PDCD5 is a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this protein is distributed in both the nucleus and cytoplasm. Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.

Product Categories/Family for anti-PDCD5 antibody

Antibodies; Apoptosis

References

Du, Y.J., et al. Chin. Med. Sci. J. 24(4):241-245(2009). Young, R.P., et al. Postgrad Med J 85(1008):515-524(2009). Salvi, M., et al. Biochem. Biophys. Res. Commun. 387(3):606-610(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4759224
• NCBI GeneID: 9141
• NCBI Accession #: NP_004699
• NCBI GenBank Nucleotide #: NM_004708.3
• UniProt Accession #: O14737; Q53YC9; Q6IB70; B4DE64
• Molecular Weight: 14 kDa (125 aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: programmed cell death protein 5
• NCBI Official Synonym Full Names: programmed cell death 5
• NCBI Official Symbol: PDCD5
• NCBI Official Synonym Symbols: TFAR19
• NCBI Protein Information: programmed cell death protein 5
• UniProt Protein Name: Programmed cell death protein 5
• Protein Family: Programmed cell death protein
• UniProt Gene Name: PDCD5
• UniProt Synonym Gene Names: TFAR19; Protein TFAR19
• UniProt Entry Name: PDCD5_HUMAN

NCBI Description

This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

Uniprot Description

PDCD5: May function in the process of apoptosis. Belongs to the PDCD5 family.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 19q13.11

Cellular Component: cytoplasm; nucleus

Molecular Function: heparin binding; protein binding; DNA binding; beta-tubulin binding

Biological Process: negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of caspase activity