Western Blot (WB)
(PCDHGC4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PCDHGC4 antibody detected the PCDHGC4 protein (arrow).)
Rabbit anti-Human PCDHGC4 Polyclonal Antibody | anti-PCDHGC4 antibody
PCDHGC4 Antibody (N-term)
Western Blot (WB)
(PCDHGC4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PCDHGC4 antibody detected the PCDHGC4 protein (arrow).)
Western Blot (WB)
(PCDHGC4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PCDHGC4 antibody detected the PCDHGC4 protein (arrow).)
cluster, one of three related clusters tandemly linked on
chromosome five. These gene clusters have an immunoglobulin-like
organization, suggesting that a novel mechanism may be involved in
their regulation and expression. The gamma gene cluster includes 22
genes divided into 3 subfamilies. Subfamily A contains 12 genes,
subfamily B contains 7 genes and 2 pseudogenes, and the more
distantly related subfamily C contains 3 genes. The tandem array of
22 large, variable region exons are followed by a constant region,
containing 3 exons shared by all genes in the cluster. Each
variable region exon encodes the extracellular region, which
includes 6 cadherin ectodomains and a transmembrane region. The
constant region exons encode the common cytoplasmic region. These
neural cadherin-like cell adhesion proteins most likely play a
critical role in the establishment and function of specific
cell-cell connections in the brain. Alternative splicing has been
described for the gamma cluster genes.
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)
Wu, Q., et al. Cell 97(6):779-790(1999)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Uniprot Description
PCDHGC4: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: integral to membrane; plasma membrane
Molecular Function: calcium ion binding
Biological Process: homophilic cell adhesion
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Product Notes
The PCDHGC4 pcdhgc4 (Catalog #AAA9214933) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 265-291. The PCDHGC4 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PCDHGC4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PCDHGC4 pcdhgc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCDHGC4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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