Rabbit PAX5 Polyclonal Antibody | anti-PAX5 antibody

PAX5 Antibody

Cat. Num. AAA5314794

• Gene Names: PAX5; ALL3; BSAP
• Applications: Western Blot
• Purity: Immunogen Affinity Chromatography
• Synonyms: PAX5; Polyclonal Antibody; PAX5 Antibody; Purified Polyclonal PAX5 Antibody; Polyclonal PAX5 antibody; Anti-PAX5 antibody; Paired box protein Pax-5 antibody; B-cell-specific transcription factor antibody; BSAP antibody; anti-PAX5 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of PAX5 protein
• Purity/Purification: Immunogen Affinity Chromatography
• Form/Format: Supplied in liquid form in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3 with 30% Glycerol and 0.01% Sodium Azide
• Sequence Length: 328

• Applicable Applications for anti-PAX5 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: PAX5 antibody was raised in Rabbit using a KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PAX5 as the immunogen
• Cross-Reactivity: Monkey
• Preparation and Storage: Store at 4 degree C for short term storage. For long term, aliquot and store at -20 degree C. Avoid repeat freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of PAX5 expression in A549 (A); Raji (B); K562 (C); U937 (D) whole cell lysates.)

Related Product Information for anti-PAX5 antibody

PAX5 is the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.

Product Categories/Family for anti-PAX5 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 525507362
• NCBI GeneID: 5079
• NCBI GenBank Nucleotide #: NP_001267481.1
• UniProt Accession #: Q02548
• NCBI Official Full Name: paired box protein Pax-5 isoform 7
• NCBI Official Synonym Full Names: paired box 5
• NCBI Official Symbol: PAX5
• NCBI Official Synonym Symbols: ALL3; BSAP
• NCBI Protein Information: paired box protein Pax-5
• UniProt Protein Name: Paired box protein Pax-5
• Protein Family: Paired box protein
• UniProt Gene Name: PAX5
• UniProt Synonym Gene Names: BSAP
• UniProt Entry Name: PAX5_HUMAN

NCBI Description

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Description

PAX5: May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. Interacts with DAXX. Binds DNA as a monomer. Binds TLE4.

Protein type: Oncoprotein

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: transcription from RNA polymerase II promoter; negative regulation of histone H3-K9 methylation; nervous system development; organ morphogenesis; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter; humoral immune response

Disease: Leukemia, Acute Lymphoblastic, Susceptibility To, 3