Rabbit anti-Human PAX5 Polyclonal Antibody | anti-PAX5 antibody

Anti-PAX5 Antibody

Cat. Num. AAA7607699

• Gene Names: PAX5; ALL3; BSAP
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen affinity purified
• Synonyms: PAX5; Polyclonal Antibody; Anti-PAX5 Antibody; BSAP; BSAP;PAX5; paired box 5; Paired box protein Pax 5; anti-PAX5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen affinity purified
• Form/Format: Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

• Applicable Applications for anti-PAX5 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:500
• Immunogen: Paired box Protein Pax-5
• Preparation and Storage: Store at -20 degree C for 24 months. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using MBS7607699 (PAX5 antibody) at dilution of 1:200)

Product Categories/Family for anti-PAX5 antibody

Epigenetics; Neuroscience

NCBI and Uniprot Product Information

• NCBI GeneID: 5079
• UniProt Accession #: Q02548 ; Q02548
• Molecular Weight: Observed MW: 42kDa
• NCBI Official Synonym Full Names: paired box 5
• NCBI Official Symbol: PAX5
• NCBI Official Synonym Symbols: ALL3; BSAP
• NCBI Protein Information: paired box protein Pax-5
• Protein Family: Paired box protein

NCBI Description

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]