Mouse anti-Human PAX5 Monoclonal Antibody | anti-PAX5 antibody

PAX5 Monoclonal Antibody

Cat. Num. AAA2540251

• Gene Names: PAX5; ALL3; BSAP
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Protein G purification
• Synonyms: PAX5; Monoclonal Antibody; PAX5 Monoclonal Antibody; B cell lineage specific activator; B cell lineage specific activator protein; B cell specific activator protein; B cell specific transcription factor; B-cell-specific transcription factor; BSAP; EBB-1; KLP; Paired box 5; Paired box gene 5 (B cell lineage specific activator protein); Paired box gene 5 (B cell lineage specific activator); Paired box gene 5; Paired box homeotic gene 5; Paired box protein Pax 5; Paired box protein Pax-5; Paired domain gene 5; PAX 5; Transcription factor PAX 5; anti-PAX5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 96
• Purity/Purification: Protein G purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 357

• Applicable Applications for anti-PAX5 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:5000; IHC: 1:50-1:500
• Immunogen: Fusion protein of BSAP/PAX5
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Ramos cells using BSAP/PAX5 Monoclonal Antibody at dilution of 1:1500)

Related Product Information for anti-PAX5 antibody

PAX5, also named B-cell specific activator protein (BSAP), is a member of the highly conserved paired box (PAX)-domain family of transcription factors. PAX5 is essential in normal B-cell lymphopoiesis. It is expressed in pro-B, pre-B and mature B lymphocytes but not in plasma cells. PAX5 is a common target in leukemogenesis of B-ALL (B-lineage acute lymphoblastic leukemia) along with CDKN2A. Owing to its frequent deletion in B-ALL, PAX5 could be used as one of the molecular markers in identification and monitoring of the disease. This antibody is specific to PAX5. It will not cross react with other PAX members.

Product Categories/Family for anti-PAX5 antibody

Cancer; Epigenetics and Nuclear Signaling; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 525507346
• NCBI GeneID: 5079
• NCBI Accession #: NP_001267476.1
• NCBI GenBank Nucleotide #: NM_001280547.1
• UniProt Accession #: Q02548; O75933; Q5SFM2; Q6S728; A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0
• Molecular Weight: Calculated: 42kDa; Observed: 42kDa
• NCBI Official Full Name: paired box protein Pax-5 isoform 2
• NCBI Official Synonym Full Names: paired box 5
• NCBI Official Symbol: PAX5
• NCBI Official Synonym Symbols: ALL3; BSAP
• NCBI Protein Information: paired box protein Pax-5
• UniProt Protein Name: Paired box protein Pax-5
• Protein Family: Paired box protein
• UniProt Gene Name: PAX5
• UniProt Synonym Gene Names: BSAP

NCBI Description

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Description

May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.