Flow Cytometry (FC/FACS)
(PAX1 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Rabbit anti-Human PAX1 Polyclonal Antibody | anti-PAX1 antibody
PAX1 Antibody (C-term)
WB~~1:1000
Flow Cytometry (FC/FACS)
(PAX1 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(PAX1 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Western Blot (WB)
(PAX1 Antibody (C-term) western blot analysis in HepG2,MDA-MB453,293,K562,MCF-7 cell line lysates (35ug/lane).This demonstrates the PAX1 antibody detected the PAX1 protein (arrow).)
Western Blot (WB)
(PAX1 Antibody (C-term) western blot analysis in HepG2,MDA-MB453,293,K562,MCF-7 cell line lysates (35ug/lane).This demonstrates the PAX1 antibody detected the PAX1 protein (arrow).)
family of developmental control genes that encode transcription
factors and have been shown to play a role in pattern formation
during embryogenesis in vertebrates (McGaughran et al., 2003
[PubMed 12774041]). See PAX7 (MIM 167410) for a discussion of
paired box domain genes.
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Hillmer, A.M., et al. Nat. Genet. 40(11):1279-1281(2008)
Richards, J.B., et al. Nat. Genet. 40(11):1282-1284(2008)
Fei, Q., et al. Zhonghua Yi Xue Za Zhi 88(37):2597-2602(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012]
Uniprot Description
PAX1: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 20p11.2
Cellular Component: nucleus
Molecular Function: DNA binding
Biological Process: transcription from RNA polymerase II promoter; cell proliferation; somitogenesis; CD8-positive, alpha-beta T cell differentiation; thymus development; CD4-positive, alpha beta T cell differentiation; positive regulation of transcription from RNA polymerase II promoter; parathyroid gland development; skeletal development
Disease: Otofaciocervical Syndrome 2
Research Articles on PAX1
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Product Notes
The PAX1 pax1 (Catalog #AAA9200972) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 443-471. The PAX1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PAX1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB). FC~~1:10~50 WB~~1:1000. Researchers should empirically determine the suitability of the PAX1 pax1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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