Rabbit anti-Human PARL Polyclonal Antibody | anti-PARL antibody

PARL Polyclonal Antibody

Cat. Num. AAA8573840

• Gene Names: PARL; PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Affinity Purification
• Synonyms: PARL; Polyclonal Antibody; PARL Polyclonal Antibody; anti-PARL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
• Sequence Length: 379

• Applicable Applications for anti-PARL antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IF: 1:50-1:200
• Immunogen: Recombinant protein of human PARL (NP_001032728.1).
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-PARL antibody

This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease.

NCBI and Uniprot Product Information

• NCBI GI #: 143811433
• NCBI GeneID: 55486
• UniProt Accession #: Q9H300
• Molecular Weight: 36kDa; 42kDa
• NCBI Official Full Name: Presenilins-associated rhomboid-like protein, mitochondrial
• NCBI Official Synonym Full Names: presenilin associated rhomboid like
• NCBI Official Symbol: PARL
• NCBI Official Synonym Symbols: PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2
• NCBI Protein Information: presenilins-associated rhomboid-like protein, mitochondrial
• UniProt Protein Name: Presenilins-associated rhomboid-like protein, mitochondrial
• Protein Family: Presenilins-associated rhomboid-like protein
• UniProt Gene Name: PARL
• UniProt Synonym Gene Names: PSARL; Pbeta
• UniProt Entry Name: PARL_HUMAN

NCBI Description

This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]

Uniprot Description

PSARL: a mitochondrial intramembrane protease that is associated with insulin resistance and type 2 diabetes. Induced in humans by caloric restriction. Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. Induced in humans by caloric restriction. Interacts with PSEN1 and PSEN2. Binds OPA1. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Protease; EC 3.4.21.105; Membrane protein, multi-pass; Mitochondrial

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus

Molecular Function: protein binding; serine-type endopeptidase activity; endopeptidase activity

Biological Process: membrane protein proteolysis; proteolysis