Western Blot (WB)
(PACRG Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PACRG antibody detected the PACRG protein (arrow).)
Rabbit anti-Human PACRG Polyclonal Antibody | anti-PACRG antibody
PACRG Antibody (N-term)
Western Blot (WB)
(PACRG Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PACRG antibody detected the PACRG protein (arrow).)
Western Blot (WB)
(PACRG Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PACRG antibody detected the PACRG protein (arrow).)
metazoans. In vertebrates, this gene is linked in a head-to-head
arrangement with the adjacent parkin gene, which is associated with
autosomal recessive juvenile Parkinson's disease. These genes are
co-regulated in various tissues and they share a bi-directional
promoter. Both genes are associated with susceptibility to leprosy.
The parkin co-regulated gene protein forms a large molecular
complex with chaperones, including heat shock proteins 70 and 90,
and chaperonin components. This protein is also a component of Lewy
bodies in Parkinson's disease patients, and it suppresses unfolded
Pael receptor-induced neuronal cell death. Multiple transcript
variants encoding different isoforms have been found for this gene.
Wilson, G.R., et al. Fertil. Steril. 93(7):2262-2268(2010)
Dagda, R.K., et al. J. Bioenerg. Biomembr. 41(6):473-479(2009)
Velez, D.R., et al. Int. J. Tuberc. Lung Dis. 13(9):1068-1076(2009)
Taylor, J.M., et al. Parkinsonism Relat. Disord. 15(6):417-421(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PACRG: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: neuron projection; mitochondrion; nucleus; cytosol; vesicle
Molecular Function: G-protein-coupled receptor binding; heat shock protein binding; chaperone binding; ubiquitin protein ligase binding; beta-tubulin binding; Hsp90 protein binding; Hsp70 protein binding; actin binding; alpha-tubulin binding
Biological Process: spermatid development
Disease: Leprosy, Susceptibility To, 2
Research Articles on PACRG
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Product Notes
The PACRG pacrg (Catalog #AAA9211988) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 46-74. The PACRG Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PACRG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PACRG pacrg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PACRG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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