Rabbit anti-Human p53AIP1 Polyclonal Antibody | anti-p53AIP1 antibody

p53AIP1 Antibody

Cat. Num. AAA9414349

• Gene Names: TP53AIP1; P53AIP1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: p53AIP1; Polyclonal Antibody; p53AIP1 Antibody; p53-regulated apoptosis-inducing protein 1; p53AIP; anti-p53AIP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 124

• Applicable Applications for anti-p53AIP1 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the amino terminus of human p53AIP1.
• Target Name: p53AIP1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of p53AIP1 in HL60 cell lysate with p53AIP1 antibody at (A) 4 and (B) 8 ug/mL.)

Immunocytochemistry (ICC)

(Immunocytochemistry of p53AIP1 in HL60 cells with p53AIP1 antibody at 10 ug/mL.)

Related Product Information for anti-p53AIP1 antibody

The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to exist; this antibody will detect all three.

Product Categories/Family for anti-p53AIP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 10798768
• NCBI GeneID: 63970
• Molecular Weight: 12,594 Da
• NCBI Official Full Name: p53AIP1
• NCBI Official Synonym Full Names: tumor protein p53 regulated apoptosis inducing protein 1
• NCBI Official Symbol: TP53AIP1
• NCBI Official Synonym Symbols: P53AIP1
• NCBI Protein Information: p53-regulated apoptosis-inducing protein 1
• UniProt Protein Name: p53-regulated apoptosis-inducing protein 1
• UniProt Gene Name: TP53AIP1
• UniProt Synonym Gene Names: p53AIP1
• UniProt Entry Name: TPIP1_HUMAN

NCBI Description

This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

p53AIP1: May play an important role in mediating p53/TP53- dependent apoptosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: mitochondrion

Biological Process: apoptosis