Rabbit anti-Human TP53AIP1 / p53AIP1 Polyclonal Antibody | anti-TP53AIP1 antibody

Rabbit Polyclonal to Human TP53AIP1 / p53AIP1

Cat. Num. AAA240388

• Gene Names: TP53AIP1; P53AIP1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: TP53AIP1 / p53AIP1; Polyclonal Antibody; Rabbit Polyclonal to Human TP53AIP1 / p53AIP1; Anti-TP53AIP1 / p53AIP1 Antibody (N-Terminus) IHC-plus; TP53AIP1; p53AIP1; Human TP53AIP1; anti-TP53AIP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: 15 amino acid peptide from near the amino terminus of human p53AIP.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 108

• Applicable Applications for anti-TP53AIP1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human TP53AIP1 / p53AIP1.
• Immunogen Type: Synthetic peptide
• Immunogen: TP53AIP1 / p53AIP1 antibody was raised against synthetic peptide from human TP53AIP1 / p53AIP1.
• Antigen Modification: N-Terminus
• Usage Summary: Immunohistochemistry: MBS240388 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS240388 was determined to be 5 ug/ml.
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-TP53AIP1 / p53AIP1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of p53AIP1 in HL60 cells with p53AIP1 antibody at 20 ug/ml.)

Immunocytochemistry (ICC)

(Immunocytochemistry of p53AIP1 in HL60 cells with p53AIP1 antibody at 10 ug/ml.)

Western Blot (WB)

(Western blot of p53AIP1 in HL60 cell lysate with p53AIP1 antibody at (A) 4 and (B) 8 ug/ml.)

Related Product Information for anti-TP53AIP1 antibody

TP53AIP1 / p53 AIP1 is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 11545827
• NCBI GeneID: 63970
• NCBI Accession #: NP_071395.1
• NCBI GenBank Nucleotide #: NM_022112.1
• UniProt Accession #: Q9HCN2; Q6NT40; Q7Z6F7; Q9HCN0; Q9HCN1
• NCBI Official Full Name: p53-regulated apoptosis-inducing protein 1
• NCBI Official Synonym Full Names: tumor protein p53 regulated apoptosis inducing protein 1
• NCBI Official Symbol: TP53AIP1
• NCBI Official Synonym Symbols: P53AIP1
• NCBI Protein Information: p53-regulated apoptosis-inducing protein 1
• UniProt Protein Name: p53-regulated apoptosis-inducing protein 1
• Protein Family: p53-regulated apoptosis-inducing protein
• UniProt Gene Name: TP53AIP1
• UniProt Synonym Gene Names: p53AIP1
• UniProt Entry Name: TPIP1_HUMAN

NCBI Description

This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

p53AIP1: May play an important role in mediating p53/TP53- dependent apoptosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Apoptosis

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: mitochondrion

Biological Process: apoptosis