Western Blot (WB)
(Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7602308 (p35 antibody) at dilution of 1:5000)
Rabbit p35 Polyclonal Antibody | anti-p35 antibody
p35 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7602308 (p35 antibody) at dilution of 1:5000)
Western Blot (WB)
(Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7602308 (p35 antibody) at dilution of 1:5000)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
Uniprot Description
CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: axon; cell soma; contractile fiber; cyclin-dependent protein kinase 5 activator complex; cytoplasm; cytosol; dendrite; dendritic spine; growth cone; intracellular membrane-bound organelle; membrane; neuromuscular junction; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density
Molecular Function: cadherin binding; calcium ion binding; cyclin-dependent protein kinase 5 activator activity; cyclin-dependent protein kinase activity; ephrin receptor binding; kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activator activity
Biological Process: acetylcholine receptor signaling, muscarinic pathway; axon guidance; axonal fasciculation; brain development; cell proliferation; cerebellum development; embryonic development; ephrin receptor signaling pathway; hippocampus development; ionotropic glutamate receptor signaling pathway; layer formation in the cerebral cortex; negative regulation of axon extension; negative regulation of transcription, DNA-dependent; neurite development; neuron adhesion; neuron differentiation; neuron migration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of neuron apoptosis; regulation of actin cytoskeleton organization and biogenesis; regulation of cyclin-dependent protein kinase activity; regulation of macroautophagy; regulation of neuron differentiation; rhythmic process; serine phosphorylation of STAT3 protein; superior olivary nucleus maturation
Research Articles on p35
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Product Notes
The p35 cdk5r1 (Catalog #AAA7602308) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The p35 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's p35 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the p35 cdk5r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "p35, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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