Rabbit P2X3 Receptor Polyclonal Antibody | anti-P2RX3 antibody

P2X3 Receptor (P2X Purinoceptor 3, P2X3, ATP Receptor, Purinergic Receptor, P2RX3)

Cat. Num. AAA631279

• Gene Names: P2RX3; P2X3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: P2X3 Receptor; Polyclonal Antibody; P2X3 Receptor (P2X Purinoceptor 3; P2X3; ATP Receptor; Purinergic Receptor; P2RX3); Anti -P2X3 Receptor (P2X Purinoceptor 3; anti-P2RX3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human P2X3 Receptor. Species Cross-Reactivity: mouse, rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.

• Applicable Applications for anti-P2RX3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot:1ug/ml; Immunohistochemistry (paraffin):1-2ug/ml
• Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of human P2X3, different from the related rat sequence by 1 aa.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-P2RX3 antibody

Purinergic receptor P2X, ligand-gated ion channel, 3, also known as P2X3, is a human gene. Its gene is mapped to 11q12. P2X purinoceptors are 397 to 492aa long and have a predicted structure of 2 short intracellular domains, 2 transmembrane-spanning regions, and a large extracellular domain.The P2X3 subunit has 43% and 47% identity with P2X1 and P2X2, respectively; 10 cysteine residues are conserved in all 3 subtypes, so that tertiary structures may also be conserved.1 P2X3 was the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel, coupled with a sensory neuron-like pharmacology,suggested that it may transduce ATP-evoked nociceptor activation. If ATP, and more specifically, P2X3 purinoceptors are involved in nociception, then the development of an antagonist selective for P2X3 could prove useful in pain relief. Lack of P2X3 in other tissues than sensory ganglia could afford a degree of specificity, leading to fewer side effects.

Product Categories/Family for anti-P2RX3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 28416925
• NCBI GeneID: 5024
• NCBI Accession #: NP_002550.2
• NCBI GenBank Nucleotide #: NM_002559.3
• UniProt Accession #: P56373; Q6DK37; Q9UQB6
• Molecular Weight: 44,289 Da
• NCBI Official Full Name: P2X purinoceptor 3
• NCBI Official Synonym Full Names: purinergic receptor P2X, ligand-gated ion channel, 3
• NCBI Official Symbol: P2RX3
• NCBI Official Synonym Symbols: P2X3
• NCBI Protein Information: P2X purinoceptor 3; ATP receptor; purinoceptor P2X3; P2X receptor, subunit 3; purinergic receptor P2X3
• UniProt Protein Name: P2X purinoceptor 3
• Protein Family: P2X purinoceptor
• UniProt Gene Name: P2RX3
• UniProt Synonym Gene Names: P2X3
• UniProt Entry Name: P2RX3_HUMAN

NCBI Description

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

Uniprot Description

P2X3: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: Golgi apparatus; cell soma; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex; lipid raft

Molecular Function: ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; generation of action potential; regulation of synaptic plasticity; positive regulation of calcium-mediated signaling; signal transduction; response to carbohydrate stimulus; response to ATP; behavioral response to pain; response to heat; response to mechanical stimulus; transport; response to hypoxia; neuromuscular synaptic transmission; response to cold; protein homooligomerization