Rabbit anti-Human P2RX3 Polyclonal Antibody | anti-P2RX3 antibody

P2RX3, CT (P2RX3, P2X purinoceptor 3, ATP receptor, Purinergic receptor) (Biotin)

Cat. Num. AAA6330210

• Gene Names: P2RX3; P2X3
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: P2RX3; Polyclonal Antibody; CT (P2RX3; P2X purinoceptor 3; ATP receptor; Purinergic receptor) (Biotin); Purinergic receptor; anti-P2RX3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-P2RX3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: P2RX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 329-356 amino acids selected from the C-terminal region of human P2RX3.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(P2RX3 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the P2RX3 antibody detected the P2RX3 protein (arrow).)

Related Product Information for anti-P2RX3 antibody

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

Product Categories/Family for anti-P2RX3 antibody

Antibodies; Receptors

References

Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010). Beneng, K., et al. Int J Oral Maxillofac Surg 39(8):815-819(2010). Nair, A., et al. Cell. Mol. Neurobiol. 30(4):505-509(2010). Jacques-Silva, M.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(14):6465-6470(2010). Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 28416925
• NCBI GeneID: 5024
• NCBI Accession #: NP_002550.2
• NCBI GenBank Nucleotide #: NM_002559.3
• UniProt Accession #: P56373; Q6DK37; Q9UQB6
• Molecular Weight: 44,289 Da
• NCBI Official Full Name: P2X purinoceptor 3
• NCBI Official Synonym Full Names: purinergic receptor P2X, ligand-gated ion channel, 3
• NCBI Official Symbol: P2RX3
• NCBI Official Synonym Symbols: P2X3
• NCBI Protein Information: P2X purinoceptor 3; ATP receptor; purinoceptor P2X3; P2X receptor, subunit 3; purinergic receptor P2X3
• UniProt Protein Name: P2X purinoceptor 3
• Protein Family: P2X purinoceptor
• UniProt Gene Name: P2RX3
• UniProt Synonym Gene Names: P2X3
• UniProt Entry Name: P2RX3_HUMAN

NCBI Description

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

Uniprot Description

P2X3: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: Golgi apparatus; cell soma; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex; lipid raft

Molecular Function: ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; generation of action potential; regulation of synaptic plasticity; positive regulation of calcium-mediated signaling; signal transduction; response to ATP; response to carbohydrate stimulus; behavioral response to pain; transport; response to heat; response to mechanical stimulus; response to hypoxia; neuromuscular synaptic transmission; response to cold; protein homooligomerization