Rabbit anti-Human P2RX6 Polyclonal Antibody | anti-P2RX6 antibody

P2RX6, ID (P2RX6, P2RXL1, P2X6, P2X purinoceptor 6, ATP receptor, P2XM, Purinergic receptor, Purinergic receptor P2X-like 1) (Azide free) (HRP)

Cat. Num. AAA6330234

• Gene Names: P2RX6; P2X6; P2XM; P2RXL1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: P2RX6; Polyclonal Antibody; ID (P2RX6; P2RXL1; P2X6; P2X purinoceptor 6; ATP receptor; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1) (Azide free) (HRP); Purinergic receptor P2X-like 1; anti-P2RX6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-P2RX6 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: P2RX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human P2RX6.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(P2RX6 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the P2RX6 antibody detected the P2RX6 protein (arrow).)

Related Product Information for anti-P2RX6 antibody

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified.

Product Categories/Family for anti-P2RX6 antibody

Antibodies; Receptors

References

Trynka, G., et al. Gut 58(8):1078-1083(2009). Luke, M.M., et al. Stroke 40(2):363-368(2009). Palomino-Doza, J., et al. Hypertension 52(5):980-985(2008). Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008). Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 227116341
• NCBI GeneID: 9127
• NCBI Accession #: NP_001153026.1; NP_005437.2
• NCBI GenBank Nucleotide #: NM_001159554.1
• UniProt Accession #: O15547; Q32MB6; Q58F04; Q6IC33; Q9UL50; F6V3D7
• Molecular Weight: 45,808 Da
• NCBI Official Full Name: P2X purinoceptor 6 isoform 2
• NCBI Official Synonym Full Names: purinergic receptor P2X 6
• NCBI Official Symbol: P2RX6
• NCBI Official Synonym Symbols: P2X6; P2XM; P2RXL1
• NCBI Protein Information: P2X purinoceptor 6
• UniProt Protein Name: P2X purinoceptor 6
• Protein Family: P2X purinoceptor
• UniProt Gene Name: P2RX6
• UniProt Synonym Gene Names: P2RXL1; P2X6; P2X6
• UniProt Entry Name: P2RX6_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

Uniprot Description

P2X6: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation; Receptor, misc.; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cell soma; integral to plasma membrane; postsynaptic density; cytoplasm; dendritic spine; integral to nuclear inner membrane; cell junction

Molecular Function: identical protein binding; transmembrane receptor activity; channel activity; purinergic nucleotide receptor activity; ATP binding; ATP-gated cation channel activity

Biological Process: muscle contraction; transport; protein heterooligomerization; signal transduction; transmembrane transport; protein homooligomerization; cation transport