Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: PAK1 knockout Hela cell lysate; Predicted MW: 61kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human PAK1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human p21 Protein Activated Kinase 1 (PAK1) Polyclonal Antibody | anti-PAK1 antibody
Biotin-Linked Polyclonal Antibody to p21 Protein Activated Kinase 1 (PAK1)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: PAK1 knockout Hela cell lysate; Predicted MW: 61kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human PAK1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: PAK1 knockout Hela cell lysate; Predicted MW: 61kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human PAK1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Uniprot Description
PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.
Protein type: EC 2.7.11.1; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 11q13.5-q14.1
Cellular Component: axon; cytoplasm; cytosol; dendrite; filamentous actin; focal adhesion; intercalated disc; intercellular junction; invadopodium; lamellipodium; nuclear membrane; plasma membrane; protein complex; ruffle; Z disc
Molecular Function: ATP binding; collagen binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: actin cytoskeleton reorganization; activation of protein kinase activity; apoptosis; branching morphogenesis of a tube; cellular response to insulin stimulus; cerebellum development; ephrin receptor signaling pathway; establishment of cell polarity; exocytosis; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; hepatocyte growth factor receptor signaling pathway; MAPK cascade; neuron projection morphogenesis; positive regulation of axon extension; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fibroblast migration; positive regulation of glucose import in response to insulin stimulus; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of JUN kinase activity; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of stress fiber formation; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular smooth muscle cell proliferation; protein amino acid phosphorylation; protein autophosphorylation; regulation of apoptosis; regulation of axonogenesis; regulation of mitotic cell cycle; response to hypoxia; Rho protein signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; wound healing
Research Articles on PAK1
Similar Products
Product Notes
The PAK1 pak1 (Catalog #AAA2096427) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to p21 Protein Activated Kinase 1 (PAK1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's p21 Protein Activated Kinase 1 (PAK1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PAK1 pak1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "p21 Protein Activated Kinase 1 (PAK1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
