Western Blot (WB)
(Western blot analysis p-PERK (Phospho-Thr 981) using 293 whole cell lysates)
Rabbit p-PERK Polyclonal Antibody | anti-p-PERK antibody
p-PERK (Phospho-Thr 982) Antibody
Western Blot (WB)
(Western blot analysis p-PERK (Phospho-Thr 981) using 293 whole cell lysates)
Western Blot (WB)
(Western blot analysis p-PERK (Phospho-Thr 981) using 293 whole cell lysates)
Western Blot (WB)
(Western blot analysis of extracts from 293 cells,untreated ortreated with insulin and MCF7 cells, untreated or treated withAnisomycin ,using PERK (Phospho-Thr 982) Antibody MBS9416902)
Western Blot (WB)
(Western blot analysis of extracts from 293 cells,untreated ortreated with insulin and MCF7 cells, untreated or treated withAnisomycin ,using PERK (Phospho-Thr 982) Antibody MBS9416902)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Uniprot Description
PERK: a transmembrane protein kinase of the PEK family resident in the endoplasmic reticulum (ER) membrane and is linked to insulin processing. Couples ER stress to translation inhibition. Stress induces autophosphorylation of its kinase domain and increases its activity. Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. A critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin d1. Forms dimers with BiP in resting cells. Oligomerizes in ER-stressed cells. LOF mutations cause Wolcott-Rallison syndrome (WRS), characterized by insulin-dependent diabetes in early infancy and, later, multiple system abnormalities. Neuronal death in Alzheimer?s and Parkinson?s diseases is thought to be due to ER stress and has been weakly linked to PEK.
Protein type: EC 2.7.11.1; Kinase, protein; Membrane protein, integral; Other group; PEK family; PEK subfamily; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; membrane
Molecular Function: enzyme binding; eukaryotic translation initiation factor 2alpha kinase activity; identical protein binding; protein binding; protein homodimerization activity; protein kinase activity; protein phosphatase binding; protein serine/threonine kinase activity
Biological Process: angiogenesis; bone mineralization; calcium-mediated signaling; caspase activation; cellular response to amino acid starvation; cellular response to glucose starvation; chondrocyte development; endocrine pancreas development; endoplasmic reticulum organization and biogenesis; ER overload response; insulin secretion; insulin-like growth factor receptor signaling pathway; negative regulation of myelination; negative regulation of translation; negative regulation of translation initiation in response to stress; ossification; peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase I promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein homooligomerization; skeletal development; unfolded protein response
Disease: Epiphyseal Dysplasia, Multiple, With Early-onset Diabetes Mellitus
Research Articles on p-PERK
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Product Notes
The p-PERK eif2ak3 (Catalog #AAA9416902) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The p-PERK (Phospho-Thr 982) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's p-PERK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000-3000. Researchers should empirically determine the suitability of the p-PERK eif2ak3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "p-PERK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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