Western Blot (WB)
(ABCB1 Antibody (L661) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCB1 antibody detected the ABCB1 protein (arrow).)
Rabbit anti-Human P-Glycoprotein Polyclonal Antibody | anti-ABCB1 antibody
P-Glycoprotein, ID (ABCB1, MDR1, PGY1, Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243) (APC)
Gene Names
ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein G Affinity Chromatography.
Synonyms
P-Glycoprotein; Polyclonal Antibody; ID (ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243) (APC); ABCB1; CD243; anti-ABCB1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein G Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Applicable Applications for anti-ABCB1 antibody
Western Blot (WB), FLISA
Application Notes
Applications are based on unconjugated antibody.
Immunogen
P-Glycoprotein (ABCB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654~684 amino acids from the center region of human ABCB1.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(ABCB1 Antibody (L661) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCB1 antibody detected the ABCB1 protein (arrow).)
Western Blot (WB)
(ABCB1 Antibody (L661) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCB1 antibody detected the ABCB1 protein (arrow).)
Related Product Information for anti-ABCB1 antibody
The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Product Categories/Family for anti-ABCB1 antibody
References
Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002). Kerb, R., et al., Pharmacogenomics 2(1):51-64 (2001). Cascorbi, I., et al., Clin. Pharmacol. Ther. 69(3):169-174 (2001). Hoffmeyer, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(7):3473-3478 (2000). Mickley, L.A., et al., Blood 91(5):1749-1756 (1998).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
141kDa
NCBI Official Full Name
multidrug resistance protein 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 1
NCBI Official Symbol
ABCB1
NCBI Official Synonym Symbols
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
NCBI Protein Information
multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance
UniProt Protein Name
Multidrug resistance protein 1
Protein Family
UniProt Gene Name
ABCB1
UniProt Synonym Gene Names
MDR1; PGY1
UniProt Entry Name
MDR1_HUMAN
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Product Notes
The ABCB1 abcb1 (Catalog #AAA6330066) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The P-Glycoprotein, ID (ABCB1, MDR1, PGY1, Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243) (APC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's P-Glycoprotein can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the ABCB1 abcb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P-Glycoprotein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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