Typical Testing Data/Standard Curve (for reference only)
Rat Follicle-stimulating hormone receptor ELISA Kit | Fshr elisa kit
Rat Follicle-stimulating hormone receptor ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to FSH-R. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated polyclonal antibody preparation specific for FSH-R and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain FSH-R, biotin-conjugated antibody and enzymeconjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The concentration of FSH-R in the samples is then determined by comparing the O.D. of the samples to the standard curve.
NCBI and Uniprot Product Information
NCBI Description
testicular receptor for follicle stimulating hormone; stimulates adenylyl cyclase activity [RGD, Feb 2006]
Uniprot Description
FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: cell surface; endosome; integral to plasma membrane
Molecular Function: follicle-stimulating hormone receptor activity; G-protein coupled receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein binding
Biological Process: adenylate cyclase activation; cellular water homeostasis; follicle-stimulating hormone signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); hormone-mediated signaling; locomotory behavior; male gonad development; negative regulation of bone resorption; neurite development; ovarian follicle development; ovulation cycle process; positive regulation of estrogen receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; primary ovarian follicle growth; regulation of chromosome organization and biogenesis; regulation of estrogen receptor signaling pathway; regulation of hormone metabolic process; regulation of MAPKKK cascade; regulation of osteoclast differentiation; regulation of protein amino acid phosphorylation; regulation of systemic arterial blood pressure; Sertoli cell development; Sertoli cell proliferation; sperm chromatin condensation; spermatid development; spermatogenesis; spermatogenesis, exchange of chromosomal proteins; transcytosis; uterus development
Research Articles on Fshr
Similar Products
Product Notes
The Rat Fshr fshr (Catalog #AAA2880132) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880132 ELISA Kit recognizes Rat Fshr. It is sometimes possible for the material contained within the vial of "Follicle-stimulating hormone receptor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
